Dehydroxyfluorafinil
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Dehydroxyfluorafinil
The skeletal formula of fluorafinil
Dehydroxyfluorafinil.png
Chemical Nomenclature
Common names dehydroxyfluorafinil, deshydroxyl-fladrafinil, modafiendz
Systematic name 2-{[bis(4-fluorophenyl)methyl]sulfinyl}-N-methylacetamide
Routes of Administration



Oral
Dosage
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.
DISCLAIMER: PW's dosage information is a summary of data gathered from users and resources. It is not a recommendation and should be verified with other sources for accuracy.
Threshold 25 - 50 mg
Light 100 mg
Common 200 mg
Strong 300 mg
Heavy 300 mg+
Duration
Total 5 - 8 hours
Onset 1 hour
Peak 3 hours
Offset 2 hours
Afterglow 2 hours









Summary sheet: Dehydroxyfluorafinil

Dehydroxyfluorafinil (also referred to as N-methyl dehydroxyfluorafinil or Modafiendz)[1] is a wakefulness-promoting agent closely related to adrafinil and modafinil. It is the bis(p-fluoro) ring-substituted derivative of adrafinil.

Chemistry

N-methyl-dehydroxyfluorafinil, or 2-{[bis(4-fluorophenyl)methyl]sulfinyl}-N-methylacetamide is a synthetic molecule of the benzhydryl class. Benzhydryl compounds are comprised of two benzene rings attached to a single carbon molecule. Dehydroxyfluorafinil contains a fluorine group bound to each benzene ring at R4. It is classified as a sulphinyl benzhydryl molecule, as it also contains a sulphinyl group, a sulphur molecule double-bonded to an oxygen molecule, attached to the carbon of the benzhydryl group. From this sulphur group at R2, an acetamide group is bound at its free carbon through a carbonyl group to an amine group. This terminal amine group is N-substituted with a methyl chain. Dehydroxyfluorafinil is structurally similar to other benzhydrl stimulants modafinil and fluorafinil, it is the bis-fluoro-N-methyl analogue of modafinil. Dehydroxyfluorafinil is named for lacking the n substituted hydroxy group of fluorafinil, which is replaced by a methyl group in this molecule.

Dehydroxyfluorafinil is the bis-fluoro-N-methyl analogue to modafinil; it contains two fluorine groups bound to each benzene ring at carbon 4 and an OH- (hydroxy) group bound to the amine of modafinil.

Pharmacology

Although dehydroxyfluorafinil has not been formally studied, its parent compound (modafinil) has recently been shown to act as a reuptake inhibitor for the neurotransmitter dopamine, evidently leading to increased extraceullular concentrations of dopamine and dopaminergic neurotransmission. This essentially allows dopamine to accumulate and be reused, causing physically stimulating and motivating effects.

It can thus be reasoned that dehydroxyfluorafinil follows a comparable or identical mechanism of action as it is extremely similar in physical structure and almost indistinguishable in terms of the subjective effects it induces.

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical effects

The physical effects of dehydroxyfluorafinil can be broken down into several components. These are described below and generally include:

  • Stimulation - In terms of its effects on the user's physical energy levels, dehydroxyfluorafinil is commonly considered to be stimulating and energetic, but can be considered as much less stimulating when compared to amphetamine. This stimulation encourages physical movement and activities such as running, playing sports, socializing, and/or exercising. The particular style of stimulation which dehydroxyfluorafinil presents can result in jaw clenching, teeth grinding, or other involuntary movements comparable to that of traditional stimulants at high doses, but are manifested much less consistently and intensely when compared to amphetamine or cocaine.
  • Dehydration - Dehydration and dry mouth commonly occur due to an increase in motivation to engage in physical activities as well as an increased sense of focus which causes one to forget to drink water.
  • Headaches - In terms of physical discomfort, fluorafanil can cause headaches especially if dehydrated, if you have not eaten food or if you have been sitting in an awkward position for an extended period of time focused intensely on a task.
  • Appetite suppression - The above components are also accompanied by a suppression of appetite which is usually much less intense in strength in comparison to the appetite suppression experienced with amphetamine.
  • Diarrhea - Dehydroxyfluorafinil has the tendency to increase the frequency of bowel movements in certain individuals.
  • Increased heart rate
  • Dizziness
  • Nausea

Cognitive effects

The cognitive effects of dehydroxyfluorafinil can be broken down into several components. These are described below and generally include:

Toxicity and harm potential

Lethal dosage

The toxicity and long-term health effects of recreational dehydroxyfluorafinil use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because flurofanil is a research chemical with very little history of human usage. Anecdotal evidence from people who have tried dehydroxyfluorafinil within the psychonaut community suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses or using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

There is no current data for the LD50 of flurofanil, but it is thought to be high.

Tolerance and addiction potential

Although it is often used on a daily basis for extended periods of time, the long-term safety and effectiveness of flurofanil have not been determined. This substance does seem to have a tolerance and does not seem to be addictive.

Dangerous interactions

Although many drugs are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

Legal issues

Dehydroxyfluorafinil is currently a grey area compound within most (if not all) parts of the world. This means that it is not known to be specifically illegal within any country, but people may still be charged for its possession under certain circumstances such as under analogue laws and with intent to sell or consume.

See also

References

  1. ↑ http://www.chemspider.com/Chemical-Structure.29785194.html#synonymsTab
  2. ↑ Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity | http://bja.oxfordjournals.org/content/95/4/434
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