Mexedrone

Mexedrone
Chemical Nomenclature
Common names	Mexedrone
Systematic name	3-methoxy-2-(methylamino)-1-(p-tolyl)propan-1-one
Class Membership
Psychoactive class	Stimulant, Entactogen
Chemical class	Cathinone
Routes of Administration
Oral Dosage WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation. This dosage and duration information has been sourced from TripSit Threshold 50 - 100 mg Light 100 - 150 mg Common 150 - 250 mg Strong 250 - 350 mg Heavy 350 mg + Duration Total 4 - 6 hours

Summary sheet: Mexedrone

Mexedrone (3-methoxy-2-(methylamino)-1-(p-tolyl)propan-1-one) is a stimulant of the cathinone chemical class with a potency of roughly 2/3rd of that of mephedrone.

This compound has little to no history of human usage prior to its release in August 2015 as a newly available grey area research chemical. It has been primarily marketed as a legal alternative to mephedrone although anecdotal reports seem to universally suggest that it is largely inferior in its recreational effects due to its weaker potency, stimulation and euphoria.

Chemistry

Mexedrone, or 3-methoxy-2-(methylamino)-1-(p-tolyl)propan-1-one, is a synthetic molecule of the cathinone family. Cathinones are structurally similar to amphetamines. They contain a phenethylamine core featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain with an additional methyl substitution at R_α. Amphetamines and cathinones are alpha-methylated phenethylamines. Cathinones contain an additional ketone group bonded at R₁.

Mexedrone contains additional methyl substitutions at R_N (similar to MDMA and methamphetamine) and R₄ of its phenyl ring. Mexedrone is named for the methoxy group (C₃O-) bound to the methyl group located at R_α. Mexedrone is closely analogous to mephedrone, however, mephedrone lacks the additional methoxy group bonded to the α-methyl group.

Pharmacology

Given its similar subjective effects and chemical structure to mephedrone, this compound is likely (but not confirmed) to act as a releasing agent and a reuptake inhibitor for monoamine neurotransmitters such as serotonin, dopamine and noradrenaline. This increase in neurotransmitters provides an explanation for the euphoric and stimulating effects induced by this experience. Anecdotal reports often state that mexedrone is more sedating than stimulating, which suggests it may release more serotonin than dopamine in a fashion that is similar to MDAI.

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical effects

• Physical euphoria
• Tactile enhancement
• Sedation - The biggest difference between mexedrone and mephedrone is that it primarily results in moderate sedation over stimulation and can therefore discourage physical activities such as running, dancing or climbing.
• Spontaneous tactile sensations - The "body high" of mexedrone can be described as a mild soft and warm tingling sensation that encompasses the entire body. This sensation maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.
• Dehydration
• Vibrating vision - At high doses, a person's eyeballs may begin to spontaneously wiggle back and forth in a rapid motion, causing the vision to become blurry and temporarily out of focus. This is a condition known as nystagmus.
• Increased perspiration
• Temperature regulation suppression
• Teeth grinding - This component can be considered to be less intense when compared with that of MDMA.

Cognitive effects

• Euphoria - Mild emotional euphoria and feelings of happiness are present within mexedrone and are likely a direct result of serotonin and dopamine release.
• Thought acceleration
• Thought connectivity

Auditory effects

• Enhancements

Toxicity and harm potential

Main article: Research chemicals § Toxicity and harm potential

The toxicity and long-term health effects of recreational mexedrone use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because mexedrone has very little history of human usage. Anecdotal evidence from people who have tried mexedrone within the community suggest that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed).

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

As with other stimulants, the chronic use of mexedrone can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage.

Tolerance to many of the effects of mexedrone develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). Mexedrone presents cross-tolerance with all dopaminergic stimulants, meaning that after the consumption of mexedrone all stimulants will have a reduced effect.

Dangerous interactions

Although many drugs are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

• 25x-NBOMe - Both the NBOMe series and this compound induce powerful stimulation and their interaction may cause severe side effects. These can include thought loops, seizures, increased blood pressure, vasoconstriction, increased heart rate, and heart failure (in extreme cases).
• Alcohol - It is dangerous to combine alcohol, a depressant, with stimulants due to the risk of excessive intoxication. Stimulants decrease the sedative effect of alcohol which is the main factor most people consider when determining their level of intoxication. Once the stimulant wears off, the effects of alcohol will be significantly increased, leading to intensified disinhibition as well as respiratory depression. If combined, one should strictly limit themselves to only drinking a certain amount of alcohol per hour.
• DXM - This combination may cause increased heart rate and panic attacks.
• MXE - Increased heart rate and blood pressure may occur.
• Tramadol - This combination can increase the risk of seizures.
• Cocaine - This combination may increase strain on the heart.

Serotonin syndrome risk

Combinations in the list below may increase the amount of neurotransmitters such as serotonin and dopamine to dangerous or even fatal levels.

• MAOIs such as syrian rue, banisteriopsis caapi, 2C-T-2, 2C-T-7, αMT, and some antidepressants
• Serotonin releasers such as MDMA, 4-FA, MDAI and αMT
• Selective serotonin re-uptake inhibitors (SSRIs)
• 5-HTP

Legal issues

This legality section is a stub. As such, it likely contains incomplete or wrong information. You can help by expanding it.

Mexedrone is currently thought to be a legal grey area drug worldwide and is easily accessible through the use of online research chemical vendors. However, this does not guarantee anyone to be immune from legal prosecution should they be found in possession of this substance as the legality is likely to vary from country to country.

• United Kingdom - It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.

See also

• Responsible use
• Mephedrone
• Cathinone
• Stimulant

External links

• Mexedrone (Wikipedia)
• Mexedrone (TripSit)
• Mexedrone (UK Chemical Research)