MDAI

MDAI
The skeletal formula of MDAI
Chemical Nomenclature
Common names	MDAI, 5,6-Methylenedioxy-2-aminoindane
Systematic name	6,7-dihydro-5H-cyclopenta[f][1,3]benzodioxol-6-amine
Routes of Administration
Oral Dosage WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation. This dosage and duration information has been sourced from TripSit Threshold 20 - 40 mg Light 40 - 100 mg Common 100 - 150 mg Strong 150 - 300 mg Heavy 300 mg + Duration Total 4 - 6 hours Onset 30 - 60 minutes Peak 3 - 5 hours Offset 3 - 4 hours After effects 24 hours

Summary sheet: MDAI

MDAI (5,6-Methylenedioxy-2-aminoindane) is a compound of the aminoindane class which was developed in the 1990s by a team led by David E. Nichols at Purdue University. It acts as a non-neurotoxic and highly selective serotonin releasing agent (SSRA) which produces entactogen effects in humans similar to that of MDMA.

Chemistry

MDAI, or 5,6-Methylenedioxy-2-aminoindane is a synthetic molecule of the aminoindane class with structural similarity to amphetamines. It features the R₃ terminal carbon of the propane chain of amphetamine bound to the benzene ring. This creates an indane group, a bicyclic moeity containing a benzene ring fused to a pentane ring. MDAI contains an amino group NH₂ bound to R₂ of the indane ring. MDAI also contains two oxygen substitutions at R₅ and R₆ joined by a methylene bridge to form a methylenedioxy group. MDAI is structurally related to 2-AI with the addition of a methylenedioxy ring.

Pharmacology

MDAI has been shown to inhibit the reuptake of serotonin and has a selective affinity for the serotonin receptor. Studies show that the brains of animals treated with MDAI have greater extracellular concentrations of monoamine neural transmitters, most significantly serotonin. For comparison, MDAI is similar in potency with releasing serotonin to MDA, but significantly less potent than MDMA. This is done by inhibiting the reuptake and reabsorption of the neurotransmitters after they have performed their function of transmitting a neural impulse, essentially allowing them to accumulate, be reused and cause entactogenic effects.

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical effects

• Physical euphoria
• Tactile enhancement
• Sedation - The biggest difference between MDAI and MDMA is that due to a comparative lack of dopamine reuptake inhibition, MDAI primarily results in moderate sedation and can therefore discourage physical activities such as running, dancing or climbing.
• Spontaneous tactile sensations - The "body high" of MDAI can be described as a moderate to extreme euphoric, soft and warm tingling sensation that encompasses the entire body. It is capable of becoming overwhelmingly pleasurable at higher doses. This sensation maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.
• Dehydration - Feelings of dry mouth and dehydration are a universal experience with MDAI; this effect is a product of an increased heart rate and an extreme motivation to engage in strenuous physical activities. While it is important to avoid becoming dehydrated (especially when out dancing in a hot environment) there have been a number of users suffering from water intoxication through over-drinking, so it is advised that users simply sip at water and never over-drink.
• Difficulty urinating - Much like MDMA, higher doses of MDAI result in difficulty urinating. This is an effect that is completely temporary and harmless. It is most likely due to the promotion of the release of anti-diuretic hormone (ADH), which is the mechanism responsible for this side effect within MDMA. Anti-diuretic hormone is responsible for regulating urination. Difficulty urinating can be lessened by simply relaxing, but can be significantly relieved by placing a hot flannel over the genitals to warm them up and encourage blood flow. Some have reported that simply listening to the sound of running water also helps (such as a tap/faucet).
• Vibrating vision - At high doses, a person's eyeballs may begin to spontaneously wiggle back and forth in a rapid motion, causing the vision to become blurry and temporarily out of focus. This is a condition known as nystagmus.
• Increased perspiration
• Temporary erectile dysfunction

Cognitive effects

The cognitive effects of MDAI can be broken down into several components which progressively intensify proportional to dosage. The general head space of MDAI is described by many as one of euphoria and feelings of love or empathy. It contains a number of typical entactogenic cognitive effects.

The most prominent of these cognitive effects generally include:

• Cognitive euphoria - Strong emotional euphoria and feelings of happiness are present within MDAI and are a direct result of serotonin release.
• Empathy, love and sociability enhancement - This particular effect is equally as pronounced, powerful and therapeutic as that of MDMA or 2C-B. It is the most obvious and noticeable effect within any MDAI experience and dominates the head space.
• Thought acceleration
• Mindfulness
• Unity and interconnectedness - At higher doses, this particular effect is equally as pronounced and powerful as MDMA.
• Immersion enhancement
• Anxiety suppression
• Time distortion

Visual effects

The visual effects of MDAI only occur at higher doses and are subtly psychedelic. These generally include:

• Visual acuity enhancement
• Colour enhancement
• Tracers

Auditory effects

• Enhancements

Toxicity and harm potential

Main article: Research chemicals § Toxicity and harm potential

MDAI and other similar drugs have been widely used in scientific research as they are able to replicate many of the effects of MDMA, but without causing the neurotoxicity which may be associated with MDMA and some related drugs. No tests have been performed on cardiovascular toxicity.

There is currently no scientific data on the lethal dose of MDAI within human beings and the exact toxic dosage is unknown but it is thought to be high in comparison to its active dose. Due to its action as a serotonin reuptake inhibitor, overdoses of this substance would likely result in acute or even fatal serotonin syndrome.

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

The chronic use of MDAI can be considered somewhat addictive with a low potential for abuse and is unlikely to be capable of causing psychological dependence among most users. This is because unlike traditional stimulants, MDAI does not increase concentrations of dopamine. If addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage.

Tolerance to many of the effects of MDAI develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). MDAI presents cross-tolerance with all serotoninergic stimulants, meaning that after the consumption of MDAI all serotonergic stimulants will have a reduced effect.

Dangerous interactions

Although many drugs are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

• 25x-NBOMe - Both the NBOMe series and this compound induce powerful stimulation and their interaction may cause severe side effects. These can include thought loops, seizures, increased blood pressure, vasoconstriction, increased heart rate, and heart failure (in extreme cases).
• Alcohol - It is dangerous to combine alcohol, a depressant, with stimulants due to the risk of excessive intoxication. Stimulants decrease the sedative effect of alcohol which is the main factor most people consider when determining their level of intoxication. Once the stimulant wears off, the effects of alcohol will be significantly increased, leading to intensified disinhibition as well as respiratory depression. If combined, one should strictly limit themselves to only drinking a certain amount of alcohol per hour.
• DXM - This combination may cause increased heart rate and panic attacks.
• MXE - Increased heart rate and blood pressure may occur.
• Tramadol - This combination can increase the risk of seizures.
• MDMA - The neurotoxic effects of MDMA may be increased when combined with other stimulants.
• Cocaine - This combination may increase strain on the heart.

Serotonin syndrome risk

Combinations in the list below may increase the amount of neurotransmitters such as serotonin and dopamine to dangerous or even fatal levels.

• MAOIs such as syrian rue, banisteriopsis caapi, 2C-T-2, 2C-T-7, αMT, and some antidepressants
• Serotonin releasers such as MDMA, 4-FA, MDAI and αMT
• Selective serotonin re-uptake inhibitors (SSRIs)
• 5-HTP

Legal issues

This legality section is a stub. As such, it likely contains incomplete or wrong information. You can help by expanding it.

• United Kingdom - It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.
• China - As of October 2015, MDAI is a controlled substance in China.
• Denmark - MDAI is illegal in Denmark as of September 2015.

See also

• Responsible use
• Entactogen
• MDMA
• MDA

External links

• MDAI (Wikipedia)
• MDAI (Erowid)
• MDAI (Bluelight)
• MDAI (TripSit)
• MDAI experiences (Erowid)