4F-MPH

4F-MPH
Chemical Nomenclature
Common names	4F-MPH, 4-FMPH
Substitutive name	4-Fluoromethylphenidate
Systematic name	methyl 2-(4-fluorophenyl)-2-(piperidin-2-yl)acetate <-- Class Membership -->
Class Membership
Psychoactive class	Stimulant
Chemical class	Phenethylamine
Routes of Administration
Oral Dosage WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation. This dosage and duration information has been sourced from TripSit Threshold < 5 mg Light 5 - 10 mg Common 10 - 15 mg Strong 15 - 20 mg Heavy 20 mg + Duration Total 4 - 7 hours Onset 25 - 40 minutes After effects 5 - 10 hours

Summary sheet: 4F-MPH

4F-MPH (4'-fluoro-methylphenidate) is a stimulant, substituted phenethylamine, piperidine, and close analog of methylphenidate (ritalin). The two substances have very similar pharmacological mechanisms but distinctively different subjective effects as 4F-MPH can be considered significantly more euphoric and recreational in its experience. It also acts as a higher efficiency dopamine reuptake inhibitor than the closely related methylphenidate.

4F-MPH has little to no history of human usage prior to its distribution online through research chemical vendors. It was initially developed as a replacement for ethylphenidate which became illegal in the United Kingdom on April 10, 2015 due to a temporary blanket ban. Anecdotal reports suggest that it is considerably more potent with fewer uncomfortable side effects such as anxiety, muscle spasms and compulsive redosing.

Chemistry

This chemistry section is incomplete. You can help by adding to it.

4F-MPH is nearly identical in structure to methylphenidate (ritalin); the difference is that it has a fluorine atom bonded to the phenyl group at the 4 position. Amphetamine analogues containing fluorine, chlorine, bromine and methyl groups are typically stronger than those without.

Pharmacology

4F-MPH acts as a dopamine reuptake inhibitor, meaning it effectively boosts the levels of dopamine neurotransmitters in the brain by binding to and partially blocking the transporter proteins that normally remove those monoamines from the synaptic cleft. This allows dopamine to accumulate within the brain, resulting in stimulating and euphoric effects.

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical effects

• Stimulation
• Dehydration
• Appetite suppression
• Increased heart rate
• Teeth grinding - This component can be considered to be less intense when compared with that of MDMA.

Cognitive effects

• Thought acceleration
• Analysis enhancement
• Wakefulness
• Focus enhancement - This component is most effective at low to moderate dosages as anything higher will usually impair concentration.
• Motivation enhancement
• Euphoria - The euphoric rush associated with 4F-MPH use (as result of dopamine reuptake inhibition) is very short-lived and compulsive, similar to that of cocaine.
• Cognitive fatigue - This component can occur during the offset of this compound as a rebound effect which is usually equal in its intensity to the enhancements which occurred before it.

Toxicity and harm potential

Main article: Research chemicals § Toxicity and harm potential

The toxicity and long-term health effects of recreational 4F-MPH use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because 4F-MPH is a research chemical with very little history of human usage. Anecdotal evidence from people who have tried 4F-MPH suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

In terms of its tolerance, 4F-MPH can be used multiple days in a row for extended periods of time, but acute tolerance does exist and builds up gradually over repeated extended use. This results in the user requiring an increase in dosage to achieve the same effects.

4F-MPH has potential for abuse on par with that of amphetamine or MDMA due to its lack of significant tolerance, euphoric effects and action upon dopamine transporters.

Dangerous interactions

Although many drugs are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

• 25x-NBOMe - Both the NBOMe series and this compound induce powerful stimulation and their interaction may cause severe side effects. These can include thought loops, seizures, increased blood pressure, vasoconstriction, increased heart rate, and heart failure (in extreme cases).
• Alcohol - It is dangerous to combine alcohol, a depressant, with stimulants due to the risk of excessive intoxication. Stimulants decrease the sedative effect of alcohol which is the main factor most people consider when determining their level of intoxication. Once the stimulant wears off, the effects of alcohol will be significantly increased, leading to intensified disinhibition as well as respiratory depression. If combined, one should strictly limit themselves to only drinking a certain amount of alcohol per hour.
• DXM - This combination may cause increased heart rate and panic attacks.
• MXE - Increased heart rate and blood pressure may occur.
• Tramadol - This combination can increase the risk of seizures.
• MAOIs - This combination may increase the amount of neurotransmitters such as dopamine to dangerous or even fatal levels. Examples include syrian rue, banisteriopsis caapi, 2C-T-2, 2C-T-7, αMT, and some antidepressants.
• MDMA - The neurotoxic effects of MDMA may be increased when combined with other stimulants.
• Cocaine - This combination may increase strain on the heart.

Legal issues

This legality section is a stub. As such, it likely contains incomplete or wrong information. You can help by expanding it.

• United Kingdom - It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.
• U.S. - 4-Fluromethylphenidate is a Schedule I controlled substance in the state of Alabama.

See also

• Responsible use
• Methylphenidate
• Ethylphenidate
• Stimulant

External links

• 4F-MPH (Wikipedia)
• 4F-MPH (Bluelight)
• 4F-MPH (UK Chemical Research)