Methiopropamine

Methiopropamine
The skeletal formula of methiopropamine
Chemical Nomenclature
Common names	Methiopropamine
Substitutive name	MPA
Systematic name	1-(thiophen-2-yl)-2-methylaminopropane
Routes of Administration
Oral Dosage WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. DISCLAIMER: PW's dosage information is a summary of data gathered from users and resources. It is NOT a recommendation and should be verified with other sources for accuracy. Threshold 10 mg Light 20 - 30 mg Common 40 - 50 mg Strong 50 - 60 mg Heavy 60 mg + Duration Total 6 - 10 hours Onset 30 - 60 minutes Peak 2 - 4 hours Offset 2 - 3 hours Afterglow 1 - 2 hours

Summary sheet: Methiopropamine

Methiopropamine (MPA) is a thiophene ring-based structural analogue of methamphetamine which was originally reported in 1942. Chemically, it is not a phenethylamine or amphetamine and is not their functional analog. It originally appeared for public sale in the U.K. in December 2010 as a research chemical or legal high, recently branded as Blow. It has limited popularity as a recreational stimulant.

Chemistry

Methiopropamine, or 1-(thiophen-2-yl)-2-methylaminopropane, is a synthetic molecule of the thiophene class. It is a structural analogue to methamphetamine. It contains a thiophene ring bound to an amino (NH2) group through an ethyl chain with an additional methyl substitution at R_α. Methiopropamine contains an additional methyl substitution at R_N (similarly to MDMA and methamphetamine). Although methiopropamine is analogous to methamphetamine, it is neither an amphetamine nor a phenethylamine as methiopropamine contains a thiophene ring instead of a benzene ring. Thiophene is a five-membered aromatic ring with a sulphur constituent.

Pharmacology

Methiopropamine functions as a selective norepinephrine-dopamine releasing agent. This allows dopamine and norepinephrine to accumulate within the brain, resulting in stimulating and euphoric effects. It is approximately one third as potent as dextroamphetamine as a norepinephrine reuptake inhibitor and one fifth as much as a dopamine reuptake inhibitor. It displays negligible activity as a serotonin reuptake inhibitor.

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical effects

The physical effects of methiopropamine can be broken down into several components which progressively intensify proportional to dosage. These are described below and generally include:

• Stimulation - In terms of its effects on the physical energy levels of the user, methiopropamine is usually considered to be mildly to moderately energetic and stimulating in a fashion that is considerably weaker in comparison to that of traditional recreational stimulants such as amphetamine, MDMA or cocaine. This encourages physical activities such as performing chores, repetitive tasks which would otherwise be boring and strenuous physical activities.
• Spontaneous tactile sensations - The "body high" of methiopropamine can be described as an intense euphoric, sharp and all-encompassing tingling sensation that remains present through the duration of the experience.
• Increased heart rate In comparison to other stimulants such as amphetamine or cocaine, methiopropamine only has a mild effect on one's heart rate.
• Appetite suppression The above components are also accompanied by a suppression of appetite which is usually much less intense in strength in comparison to the appetite suppression experienced with amphetamine or methamphetamine.
• Increased perspiration
• Sexual arousal
• Temperature regulation suppression

Cognitive effects

The cognitive effects of methiopropamine can be broken down into several components which progressively intensify proportional to dosage. It contains a large number of typical stimulant cognitive effects. Although negative side effects are usually mild at low to moderate doses, they become increasingly likely to manifest themselves with higher amounts or extended usage. This particularly holds true during the offset of the experience.

The most prominent of these cognitive effects generally include:

• Focus enhancement - This component is most effective at low to moderate doses as anything higher will usually impair concentration.
• Cognitive euphoria - This component is much less intense than the euphoria experienced with other stimulants such as amphetamine, cocaine, or methamphetamine.
• Wakefulness
• Thought acceleration
• Analysis enhancement
• Motivation enhancement
• Anxiety
• Compulsive redosing

Toxicity and harm potential

The toxicity and long-term health effects of recreational methiopropamine use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because methiopropamine is a research chemical with very little history of human usage. Anecdotal evidence from people who have tried methiopropamine suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses or using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

Tolerance and addiction potential

In terms of its tolerance, methiopropamine can be used multiple days in a row for extended periods of time, but acute tolerance does exist and builds up gradually over repeated extended use. This results in the user requiring an increase in dosage to achieve the same effects.

Methiopropamine has potential for abuse on par with that of amphetamine or MDMA due to its lack of significant tolerance, euphoric effects and action upon dopamine transporters.

It is worth noting that the addiction potential is increased when methiopropamine is crushed and insufflated (snorted) or injected.

Dangerous interactions

Although many drugs are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

• 25x-NBOMe - Both the NBOMe series and MPA induce powerful stimulation. Side effects such as thought loops, seizures, increased blood pressure, vasoconstriction, increased heart rate, and heart failure (in extreme cases) may occur.
• Alcohol - It is dangerous to combine alcohol, a depressant, with stimulants due to the risk of excessive intoxication. Stimulants decrease the sedative effect of alcohol which is the main factor most people consider when determining their level of intoxication. Once the stimulant wears off, the effects of alcohol will be significantly increased, leading to intensified disinhibition as well as other effects. If combined, one should strictly limit themselves to only drinking a certain amount of alcohol per hour.
• DXM - This combination may cause increased heart rate and panic attacks (in extreme cases).
• MXE - Increased heart rate and blood pressure may occur.
• Tramadol - This combination can increase the risk of seizures.
• MDMA - The neurotoxic effects of MDMA may be increased when combined with other stimulants.
• MAOIs - This combination may increase the amount of neurotransmitters such as dopamine to dangerous or even fatal levels. Examples include syrian rue, banisteriopsis caapi, 2C-T-2, 2C-T-7, αMT, and some antidepressants.
• Cocaine - This combination will increase strain on the heart.

Legal issues

• Finland - Methiopropamine is illegal in Finland.
• Germany - Methiopropamine is illegal in Germany.
• United Kingdom - Methiopropamine has been temporary banned in the UK for 1 year from Friday 27th Nov 2015. However it is still legal to possess.
• United States - Methiopropamine is not scheduled at the federal level in the United States, but it could be considered an analog of methamphetamine in which case purchase, sale, or possession could be prosecuted under the Federal Analog Act. Methiopropamine's structure differs from methamphetamine's structure significantly more than previous successful prosecutions under the same law.
  • Florida - Methiopropamine is a Schedule I controlled substance in the state of Florida, making it illegal to buy, sell, or possess in Florida.

See also

• Responsible use
• Methiopropamine (Wikipedia)
• Methamphetamine
• Amphetamine
• Stimulant