Metizolam

Death may occur when thienodiazepines are combined with depressants such as opiates, benzodiazepines, alcohol or other GABAergic substances.

It is strongly discouraged to consume moderate to heavy dosages of these substances together.

Metizolam
Chemical Nomenclature
Common names	Metizolam, Desmethyletizolam
Systematic name	4-(2-chlorophenyl)-2-ethyl-6H-thieno[3,2-f] [1,2,4]triazolo[4,3-a] [1,4]diazepine
Class Membership
Psychoactive class	Depressant
Chemical class	Thienodiazepine
Routes of Administration
Oral Dosage WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy. Threshold < 1 mg Light 1 - 2 mg Common 2 - 4 mg Strong 4 - 6 mg Heavy 6 mg + Duration Total 5 - 8 hours Onset 30 - 90 minutes After effects 10 - 30 hours

Summary sheet: Metizolam

Metizolam (also known as desmethyletizolam) is a short-acting psychoactive drug of the thienodiazepine class that is closely related to etizolam. It has a 60% longer half-life than etizolam but is 50% less potent than it. It has been shown by annecdotal reports to produce depressants, anxiolytic, sedative, muscle relaxant, and amnestic effects.

This compound was patented by a Japanese company in 1995 as an anti-anxiety medication. Despite this, however, it has little to no history of human usage prior to its release as a grey area research chemical by online vendors in September 2015.

Similar to benzodiazepines, the sudden discontinuation of thienodiazepines can be potentially dangerous or life-threatening for individuals using regularly for extended periods of time, sometimes resulting in seizures or death. It is highly recommended to taper one's dose by gradually lowering the amount taken each day for a prolonged period of time instead of stopping abruptly.

Chemistry

Metizolam, or desmethyletizolam, is a structural relative of benzodiazepines whereby the benzene ring has been replaced by a thiophene ring, classifying it as a thienodiazepine. It differs structurally from its parent compound etizolam through the removal of the methyl group on the triazole ring.

Metizolam contains a thiophene ring fused to a diazepine ring, which is a seven member ring with the two nitrogen constituents located at R₁ and R₄. Thiophene is a five member aromatic ring with one sulfur atom. This forms the thienodiazepine core of metizolam. An ethyl chain is bound to this bicyclic structure at R₇.

Additionally, an R₂ chlorine-substituted phenyl ring is bound to this structure at R₅. Metizolam also contains a triazole ring fused to and incorporating R₁ and R₂ of its diazepine ring. Deschloroetizolam shares this fused triazole ring substitution with certain benzodiazepine drugs called triazolobenzodiazepines (distinguished by the suffix "-zolam").

Pharmacology

Thienzodiazepines produce a variety of effects by binding to the benzodiazepine receptor site and magnifying the efficiency and effects of the neurotransmitter gamma aminobutyric acid (GABA) by acting on its receptors. As this site is the most prolific inhibitory receptor set within the brain, its modulation results in the sedating (or calming effects) of metizolam on the nervous system.

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical effects

• Sedation
• Motor control loss
• Respiratory depression
• Muscle relaxation
• Dizziness

Cognitive effects

• Anxiety suppression
• Thought deceleration
• Analysis suppression
• Disinhibition
• Information processing suppression
• Euphoria
• Compulsive redosing
• Amnesia
• Emotion suppression - Although this compound primarily suppresses anxiety, it also dulls other emotions in a manner which is distinct but less intensive than that of antipsychotics.
• Delusions of sobriety - This is the false belief that one is perfectly sober despite obvious evidence to the contrary such as severe cognitive impairment and an inability to fully communicate with others. It most commonly occurs at heavy dosages.

Toxicity and harm potential

Main article: Research chemicals § Toxicity and harm potential

The toxicity and long-term health effects of recreational metizolam use have not been studied in any scientific context and the exact toxic dosage is unknown. This is because metizolam is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried metizolam suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

Lethal dosage

The lethal dosage of metizolam has not been established; however, (like many benzodiazepines) it has a large therapeutic index and margin of safety. Complications may arise when administered in excess as this compound has not been formally studied and has little to no history of human usage.

As with all GABAergic drugs, overdose can be lethal when mixed with other depressants including alcohol or opioids.

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

Thienzodiazepines are extremely addictive. Tolerance to the sedative-hypnotic effects develops within a couple of days of repeated administration. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). Metizolan presents cross-tolerance with all thienzodiazepines and benzodiazepines, meaning that after the consumption of metizolam all compounds of the same class will have a reduced effect.

Abrupt discontinuation of metizolam following regular dosing over several days can result in a withdrawal phase which includes rebound symptoms such as increased anxiety and insomnia. It is possible to gradually reduce the dose over the course of several days, which will lengthen the duration of the withdrawal period, but reduce the perceived intensity.

Thienzodiazepine discontinuation is notoriously difficult; it is potentially life-threatening for individuals using regularly to discontinue use without tapering their dose over a period of weeks. There is an increased risk of seizure following discontinuation. Drugs which lower the seizure threshold such as tramadol should be avoided during withdrawal.

Dangerous interactions

Although many drugs are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

• Depressants (1,4-Butanediol, 2-methyl-2-butanol, alcohol, barbiturates, GHB/GBL, methaqualone, opioids) - This combination can result in dangerous or even fatal levels of respiratory depression. These substances potentiate the muscle relaxation, sedation and amnesia caused by one another and can lead to unexpected loss of consciousness at high doses. There is also an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If this occurs, users should attempt to fall asleep in the recovery position or have a friend move them into it.
• Dissociatives - This combination can result in an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If this occurs, users should attempt to fall asleep in the recovery position or have a friend move them into it.
• Stimulants - It is dangerous to combine thienzodiazepines with stimulants due to the risk of excessive intoxication. Stimulants decrease the sedative effect of benzodiazepines, which is the main factor most people consider when determining their level of intoxication. Once the stimulant wears off, the effects of thienzodiazepines will be significantly increased, leading to intensified disinhibition as well as other effects. If combined, one should strictly limit themselves to only dosing a certain amount of thienzodiazepines per hour. This combination can also potentially result in severe dehydration if hydration is not monitored.

Legal issues

This legality section is a stub. As such, it likely contains incomplete or wrong information. You can help by expanding it.

Metizolam is currently a grey area compound within most parts of the world. This means that it is not known to be specifically illegal within any country, but people may still be charged for its possession under certain circumstances such as under analogue laws and with intent to sell or consume.

• United Kingdom - It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.
• Sweden - Following its sale as a designer drug, metizolam was made illegal in Sweden on 26 January 2016.

Preparation methods

Preparation methods for this compound within our tutorial index include:

• Volumetric liquid dosing

See also

• Responsible use
• Etizolam
• Thienodiazepine
• Benzodiazepine

External links

• Metizolam (Wikipedia)
• Metizolam (Tripsit)
• Metizolam (Bluelight)
• Metizolam (UK Chemical Research)