Tryptamine

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Substitutive structure of a tryptamine molecule

Tryptamine is a mono-amine alkaloid found in animals, plants and fungi.

Substituted tryptamine refers to a class of compounds which typically produce strong psychedelic effects.

Chemistry

Tryptamine comprises an indole ring attached to a mono-amine chain.

Hydrogen atoms around the structure can be substituted for other functional groups to produce drugs of varying potency, affinity, efficacy and half-life.

Pharmacology

Main article: Serotonergic psychedelic

The psychedelic effects of tryptamines are believed to come from their efficacy at the 5-HT_2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Several neurotransmitters are derived from tryptamine, such as:

• Serotonin(5-HO-T)
• Melatonin(5-MeO-N-Acetyl-T)

Substitutions

List

• α-MT
• 4-AcO-DiPT
• Psilacetin (4-AcO-DMT)
• 4-AcO-MET
• Ethocin (4-HO-DET)
• 4-HO-MET (Metocin)
• Psilocin (4-HO-DMT)
• 4-HO-MiPT
• Psilocybin (4-PO-DMT)
• Bufotenin (5-HO-DMT)
• 5-MeO-DMT
• 5-MeO-DALT
• 5-MeO-MiPT
• Diisopropyltryptamine (DiPT)
• Dimethyltryptamine (DMT)
• Dipropyltryptamine (DPT)
• Ibogaine

Table

From Isomerdesign

	RN1	RN2	Rα	R4	R5
4-AcO-DMT	CH₃	CH₃		O-C(=O)-CH₃
4-AcO-DiPT
4-AcO-MET	CH₃	CH₂CH₃		OH
4-HO-DET
4-HO-MET
4-HO-MPT
4-HO-MiPT	CH(CH₃)₂	CH₃		OH
5-MeO-DALT
5-MeO-DMT	CH₃	CH₃			CH₂-O-CH₃
5-MeO-DiPT
5-MeO-MiPT	CH(CH₃)₂	CH₃		OCH₃
DMT	CH₃	CH₃
DPT
DiPT
Melatonin
Psilocin	CH₃	CH₃		OH
ΑMT			CH₃

See also

• Responsible use
• Tryptamine (Wikipedia)
• Alexander Shulgin
• Phenethylamine
• Lysergamide

References

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