4-HO-MET
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4-HO-MET
The skeletal formula of 4-HO-MET
4-HO-MET.png
4-OH-MET 3D.png
Chemical Nomenclature
Common names metocin, methylcybin, colours
Substitutive name 4-HO-MET
Systematic name 3-(2-(ethyl(methyl)amino)ethyl)-1H-indol-4-ol
Class Membership
Psychoactive class Psychedelic
Chemical class Tryptamine
Routes of Administration


Smoked
Dosage
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.
DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Threshold 5 - 10 mg
Light 10 - 25 mg
Common 25 - 35 mg
Strong 35 - 60 mg
Heavy 60 mg +
Duration
Total 25 - 45 minutes
Onset 15 seconds - 2 minutes
Oral
Dosage
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.
DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Threshold 2 - 8 mg
Light 5 - 10 mg
Common 8 - 15 mg
Strong 15 - 30 mg
Heavy 30 - 45 mg +
Duration
Total 4 - 6 hours
Onset 5 - 90 minutes
Come up 5 - 30 minutes
Peak 90 minutes - 6 hours
Offset 2 - 4 hours
After effects up to 12 hours









Summary sheet: 4-HO-MET

4-HO-MET (4-hydroxy-N-methyl-N-ethyltryptamine, metocin or methylcybin) is a lesser known psychedelic tryptamine. It is a structural and functional analog of psilocin as well as the 4-hydroxyl analog of MET. 4-HO-MET was first synthesized by Alexander Shulgin. In his book TiHKAL (Tryptamines I Have Known and Loved), the dosage is listed as 10-20 mɡ.[1] However, this varies greatly as some report very heavy experiences with doses as low as 17mg and others report light experiences with doses as high as 30 mg.[2]

4-HO-MET produces psilocin-like effects. Very little data exists about the pharmacological properties, metabolism, and toxicity of 4-HO-MET. There have been no reports of deaths from 4-HO-MET even though people have reported taking doses up to 150 mg.[3][4]

It is worth noting that this compound has similar subjective effects to 4-AcO-MET. Although human studies concerning the metabolic fate of this drug are lacking, this similarity is hypothesized to be a result of 4-AcO-MET quickly being hydrolyzed into the free phenolic 4-HO-MET. This is similar to how 4-AcO-DMT is thought to be deacetylated to 4-HO-DMT during first pass metabolism and subsequent passes through the liver.

Chemistry

4-HO-MET, or 4-hydroxy-N-methyl-N-ethyltryptamine, is a synthetic indole alkaloid molecule of the tryptamine class. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R3 to an amino group via an ethyl side chain. 4-HO-MET is substituted at R4 of its indole heterocycle with a hydroxyl functional group OH−. It also contains a methyl group and an ethyl chain bound to the terminal amine RN of its tryptamine backbone (MET). 4-HO-MET is a 4-hydroxy analogue of 4-AcO-MET and the N-substituted ethyl homologue of 4-HO-DMT.[5]

Pharmacology

Main article: Serotonergic psychedelic

4-HO-MET's psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical effects

  • Spontaneous tactile sensations - The "body high" of 4-HO-MET can be described as a pleasurable, warm, soft and all-encompassing tingling sensation. This maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.
  • Nausea
  • Pupil dilation
  • Sedation - In terms of its effects on the physical energy levels of the tripper, 4-HO-MET is considered by most to be relaxing, stoning and mildly sedating. This sense of sedation is often accompanied by compulsive yawning.

Cognitive effects

The cognitive effects of 4-HO-MET are described by many as somewhat relaxing yet fast-paced in style with similarities to psychedelics such as LSD or 2C-B which tend to be cognitively energetic and stimulating.

Visual effects

A noteworthy aspect regarding this compound is that at sub-psychedelic doses, it appears to still produce visual effects without any accompanying cognitive effects or "head space."

Enhancements

Distortions

Geometry

The visual geometry that is present throughout this trip can be described as somewhat similar in appearance to that of psilocin (4-HO-DMT) and 4-HO-MiPT but with far stronger synthetic digital undertones reminiscent of LSD or 2C-B. 4-HO-MET can be comprehensively described through its variations as intricate in complexity, abstract in form, equally synthetic and organic in style, structured in organization, extremely brightly lit and multicoloured in scheme, glossy in shading, sharp in edges, large in size, fast in speed, smooth in motion, angular in corners, non-immersive in depth and consistent in intensity. The visuals have a contradictory natural and synthetic feel to them which is reminiscent of both LSD and psilocybin.

Hallucinatory states

4-HO-MET and its various other forms produce a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. These effects generally include:

Auditory effects

Toxicity and harm potential

Lolol.pngMain articles: Research chemicals § Toxicity and harm potential & Responsible use § Hallucinogens

The toxicity and long-term health effects of recreational 4-HO-MET use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 4-HO-MET is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried 4-HO-MET suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption. It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

4-HO-MET is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of 4-HO-MET are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 4-HO-MET presents cross-tolerance with all psychedelics, meaning that after the consumption of 4-HO-MET all psychedelics will have a reduced effect.

Legal issues

  • Sweden - Sveriges Riksdag added 4-HO-MET to Schedule I ("substances, plant materials and fungi which normally do not have medical use") as narcotics in Sweden as of May 1, 2012. It was published by Medical Products Agency in their regulation "LVFS 2012:6" listed as "4-HO-MET 3-[2-[etyl(metyl)amino]etyl]-1H-indol-4-ol."[6]
  • U.K. - 4-HO-MET is a Class A drug in the U.K. as a result of the tryptamine catch-all clause.

Experience reports

Anecdotal reports which describe this compound within our experience index include:

Additional experience reports can be found here:

See also

External links

References

  1. ↑ https://www.erowid.org/library/books_online/tihkal/tihkal21.shtm
  2. ↑ https://www.erowid.org/chemicals/4_ho_met/4_ho_met_dose.shtml
  3. ↑ Cosmic Mind Orgy | https://www.erowid.org/experiences/exp.php?ID=71218
  4. ↑ http://www.erowid.org/experiences/exp.cgi?S1=436&S2=-1&C1=-1&Str=
  5. ↑ http://isomerdesign.com/PiHKAL/read.php?domain=tk&id=21
  6. ↑ https://lakemedelsverket.se/upload/lvfs/LVFS_2012_6.pdf
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