4-AcO-MET

4-AcO-MET
The skeletal formula of Metacetin.
Chemical Nomenclature
Common names	4-Acetoxy-MET; Metacetin; 4-Acetoxy-N-methyl-N-ethyltryptamine
Systematic name	3-(2-Ethyl(methyl)aminoethyl)-1H-indol-4-yl acetate
Class Membership
Psychoactive class	Psychedelic
Chemical class	Tryptamine
Routes of Administration
Oral Dosage WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy. Threshold 5 - 10 mg Light 10 - 20 mg Common 20 - 30 mg Strong 30 - 40 mg Heavy 40 mg + Duration Total 4 - 6 hours Onset 20 - 60 minutes Peak 1 - 2 hours Offset 2 - 4 hours After effects 1 - 5 hours

Summary sheet: 4-AcO-MET

4-Acetoxy-MET (4-Acetoxy-N-methyl-N-ethyltryptamine, metacetin or 4-AcO-MET) is a psychedelic tryptamine thought to be a serotonergic psychedelic similar to 4-AcO-DMT, LSD and DMT. Its molecular structure and pharmacological effects resemble those of the tryptamine psilocin which is the primary psychoactive chemical in magic mushrooms.

4-AcO-MET is commonly sold as a research chemical through the use of online vendors. In terms of its effects, it can be vaguely described as somewhat more synthetic in feel to that of other tryptamines but with a shorter duration.

Chemistry

General formula of a tryptamine molecule.

4-AcO-MET or 4-Acetoxy-N-methyl-N-ethyltryptamine is a synthetic indole alkaloid molecule of the tryptamine class. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R₃ to an amino group via an ethyl side chain. 4-AcO-MET is substituted at R₄ of its indole heterocycle with an acetoxy (AcO) functional group CH₃COO−. It also contains a methyl group and an ethyl chain bound to the terminal amine R_N of its tryptamine backbone (MET). 4-AcO-MET is an acetate ester analogue of 4-HO-MET and the N-substituted ethyl homologue of 4-AcO-DMT.

Pharmacology

Main article: Serotonergic psychedelic

4-AcO-MET's psychedelic effects are believed to come from its efficacy at the 5-HT_2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

It is also hypothesized that this compound is quickly hydrolyzed into the free phenolic 4-HO-MET, although human studies concerning the metabolic fate of this drug are lacking. This would explain a somewhat similar experience in their subjective effects. This is similar to how 4-AcO-DMT is thought to be deacetylated to 4-HO-DMT during first pass metabolism and subsequent passes through the liver.

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical effects

• Spontaneous tactile sensations - The "body high" of 4-AcO-MET can be described as a pleasurable, warm, soft and all-encompassing tingling sensation. This maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.
• Nausea
• Pupil dilation
• Sedation - In terms of its effects on the physical energy levels of the tripper, 4-AcO-MET is considered by most to be relaxing, stoning and mildly sedating. This sense of sedation is often accompanied by compulsive yawning.

Cognitive effects

The cognitive effects of 4-AcO-MET are described by many as somewhat relaxing, yet fast-paced in style with similarities to psychedelics such as LSD or 2C-B which tend to be cognitively energetic and stimulating. The drug contains a large number of typical and unique psychedelic cognitive effects.

The most prominent of these typical effects generally include:

• Analysis enhancement
• Conceptual thinking
• Delusions
• Direct communication with the subconscious
• Ego death
• Emotion enhancement
• Increased music appreciation
• Feelings of interdependent opposites
• Immersion enhancement
• Memory suppression
• Novelty enhancement
• Personal bias suppression
• Thought acceleration
• Thought connectivity
• Thought loops
• Time distortion
• Unity and interconnectedness
• Wakefulness

Visual effects

It's worth noting that this compound still produces visual effects at lower doses without any accompanying cognitive effects or "head space."

Enhancements

• Colour enhancement
• Pattern recognition enhancement
• Acuity enhancement

Distortions

• Drifting (Melting, Flowing, Breathing and morphing) - In comparison to other psychedelics, this effect can be described as highly detailed, cartooon-like in style, slow and smooth in motion and static in appearance.
• After images
• Colour shifting
• External geometry
• Scenery slicing
• Symmetrical texture repetition
• Tracers

Geometry

The visual geometry that is present throughout this trip can be described as somewhat similar in appearance to that of Psilocin, 4-AcO-DMT and 4-HO-MiPT but with far stronger synthetic digital undertones reminiscent of LSD or 2C-B. 4-AcO-MET can be comprehensively described through its variations as intricate in complexity, abstract in form, equally synthetic and organic in style, structured in organization, extremely brightly lit and multicoloured in scheme, glossy in shading, sharp in edges, large in size, fast in speed, smooth in motion, angular in corners, non-immersive in depth and consistent in intensity. The visuals have a contradictory "natural" and "synthetic" feel to them which is reminiscent of both LSD and and Psilocybin. Higher dosages are significantly more likely to result in states of level 8A visual geometry over level 8B.

Hallucinatory states

4-AcO-MET and its various other forms produce a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. These effects generally include:

• Transformations
• Internal hallucinations (autonomous entities; settings, sceneries, and landscapes; alterations in perspective and scenarios and plots) - This effect is very consistent in dark environments at appropriately high dosages. They can be comprehensively described through their variations as lucid in believability, interactive in style, new experiences in content, autonomous in controllability, geometry-based in style and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.

Auditory effects

• Enhancements
• Distortions
• Hallucinations

Toxicity and harm potential

Main articles: Research chemicals § Toxicity and harm potential & Responsible use § Hallucinogens

The toxicity and long-term health effects of recreational 4-AcO-MET use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 4-AcO-MET is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried 4-AcO-MET suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption. It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

4-AcO-MET is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of 4-AcO-MET are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 4-AcO-MET presents cross-tolerance with all psychedelics, meaning that after the consumption of 4-AcO-MET all psychedelics will have a reduced effect.

Legal issues

This legality section is a stub. As such, it likely contains incomplete or wrong information. You can help by expanding it.

• USA - 4-Acetoxy-MET is unscheduled in the United States, but the possession and sale of 4-Acetoxy-MET could possibly be prosecuted under the Federal Analog Act if intent to consume can be proven because of its structural similarities to psilocin.
• United Kingdom - It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.

See also

• Responsible use
• Psilocin
• Psychedelic
• Tryptamine
• 4-HO-MET
• 4-AcO-DMT

External links

• 4-AcO-MET (Wikipedia)
• 4-AcO-MET (Bluelight)
• 4-AcO-MET experiences (Erowid)
• 4-AcO-MET (Tripsit)