4-HO-DET |
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This article is a stub. As such, it likely contains incomplete or wrong information. You can help by expanding it. |
| 4-HO-DET | |||||||||||||||||||
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| Chemical Nomenclature | |||||||||||||||||||
| Common names | 4-HO-DET, 4-hydroxy-diethyl-tryptamine, CZ-74 or ethocin | ||||||||||||||||||
| Systematic name | 3-(2-diethylaminoethyl)-1H-indol-4-ol | ||||||||||||||||||
| Class Membership | |||||||||||||||||||
| Psychoactive class | Psychedelic | ||||||||||||||||||
| Chemical class | Tryptamine | ||||||||||||||||||
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| Summary sheet: 4-HO-DET |
4-HO-DET (also known as 4-hydroxy-diethyl-tryptamine, CZ-74, or ethocin) is a hallucinogenic psychedelic drug of the tryptamine family.
This compound was first discovered in the late 1950s by Albert Hofmann and Franz Troxler.[1][2] The substance was used together with its phosphoryloxy-analog 4-PO-DET in human clinical trials in the 1960s by the German researchers Hanscarl Leuner and G. Baer.
Today it is used as a recreational or entheogenic compound through the use of online research chemical vendors. It remains relatively uncommon and has very little history of human usage.
Contents
Chemistry
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This chemistry section is incomplete. You can help by adding to it. |
Pharmacology
4-HO-DET acts as a 5-HT2A partial agonist. The psychedelic effects are believed to come from 4-HO-DET's efficacy at the 5-HT2A receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.
Subjective effects
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This subjective effect breakdown is a stub. As such, it may contain incomplete or wrong information and is still in progress. You can help by expanding it. |
The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.
Physical effects
- Spontaneous tactile sensations
- Bodily control enhancement
- Increased heart rate
- Nausea
- Pupil dilation
- Tactile enhancement
Cognitive effects
- Analysis enhancement
- Conceptual thinking
- Delusions
- Emotion enhancement
- Immersion enhancement
- Memory suppression
- Novelty enhancement
- Personal bias suppression
- Thought acceleration
- Thought loops
- Time distortion
- Unity and interconnectedness
- Wakefulness
Visual effects
Enhancements
Distortions
- Drifting (melting, breathing, morphing and flowing)
- Colour shifting
- Depth perception distortions
- Perspective distortions
- Symmetrical texture repetition
- Tracers
Geometry
Hallucinatory states
- Transformations
- Internal hallucinations (autonomous entities; settings, sceneries, and landscapes; alterations in perspective and scenarios and plots)
Auditory effects
Toxicity and harm potential
 Main articles: Research chemicals § Toxicity and harm potential & Responsible use § Hallucinogens
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The toxicity and long-term health effects of recreational 4-HO-DET use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 4-HO-DET is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried 4-HO-DET suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
It is strongly recommended that one use harm reduction practices when using this drug.
Tolerance and addiction potential
4-HO-DET is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.
Tolerance to the effects of 4-HO-DET are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 4-HO-DET presents cross-tolerance with all psychedelics, meaning that after the consumption of 4-HO-DET all psychedelics will have a reduced effect.
Legal issues
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This legality section is a stub. As such, it likely contains incomplete or wrong information. You can help by expanding it. |
- United Kingdom - It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.[3]
- Sweden - 4-HO-DET is classified as a health hazard under the Act on the Prohibition of Certain Goods Dangerous to Health as of November 1, 2005 in the regulation SFS 2005:733, making it illegal to sell or possess.[4]
See also
External links
References
- ↑ Therapeutic indoles for psychic stimulation and relief of mental depression | http://www.google.com/patents/US3072530
- ↑ United States Patent Office | https://www.erowid.org/archive/rhodium/pdf/psilocin.esters.pdf
- ↑ Psychoactive Substances Act 2016 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/2016/2/contents/enacted
- ↑ Svensk författningssamling | http://www.notisum.se/rnp/sls/sfs/20050733.pdf
