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Tryptamine is a mono-amine alkaloid found in animals, plants and fungi.
Substituted tryptamine refers to a class of compounds which typically produce strong psychedelic effects.
Chemistry
Tryptamine comprises an indole ring attached to a mono-amine chain.
Hydrogen atoms around the structure can be substituted for other functional groups to produce drugs of varying potency, affinity, efficacy and half-life.
Pharmacology
The psychedelic effects of tryptamines are believed to come from their efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.
Several neurotransmitters are derived from tryptamine, such as:
Substitutions
List
- α-MT
- 4-AcO-DiPT
- Psilacetin (4-AcO-DMT)
- 4-AcO-MET
- Ethocin (4-HO-DET)
- 4-HO-MET (Metocin)
- Psilocin (4-HO-DMT)
- 4-HO-MiPT
- Psilocybin (4-PO-DMT)
- Bufotenin (5-HO-DMT)
- 5-MeO-DMT
- 5-MeO-DALT
- 5-MeO-MiPT
- Diisopropyltryptamine (DiPT)
- Dimethyltryptamine (DMT)
- Dipropyltryptamine (DPT)
- Ibogaine
Table
| RN1 | RN2 | Rα | R4 | R5 | |
|---|---|---|---|---|---|
| 4-AcO-DMT | CH₃ | CH₃ | O-C(=O)-CH₃ | ||
| 4-AcO-DiPT | |||||
| 4-AcO-MET | CH₃ | CH₂CH₃ | OH | ||
| 4-HO-DET | |||||
| 4-HO-MET | |||||
| 4-HO-MPT | |||||
| 4-HO-MiPT | CH(CH₃)₂ | CH₃ | OH | ||
| 5-MeO-DALT | |||||
| 5-MeO-DMT | CH₃ | CH₃ | CH₂-O-CH₃ | ||
| 5-MeO-DiPT | |||||
| 5-MeO-MiPT | CH(CH₃)₂ | CH₃ | OCH₃ | ||
| DMT | CH₃ | CH₃ | |||
| DPT | |||||
| DiPT | |||||
| Melatonin | |||||
| Psilocin | CH₃ | CH₃ | OH | ||
| ΑMT | CH₃ |
See also
References
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