Escaline |
| Escaline | |||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 |
|||||||||||||||||||||||||
| Chemical Nomenclature | |||||||||||||||||||||||||
| Common names | Escaline | ||||||||||||||||||||||||
| Substitutive name | 3,5-methoxy-4-ethoxyphenethylamine | ||||||||||||||||||||||||
| Systematic name | 2-(4-Ethoxy-3,5-dimethoxy-phenyl)-ethylamine | ||||||||||||||||||||||||
| Routes of Administration | |||||||||||||||||||||||||
|
|
|||||||||||||||||||||||||
| Summary sheet: Escaline |
Escaline, or 3,5-methoxy-4-ethoxyphenethylamine, is a psychedelic drug and entheogen of the phenethylamine class of compounds. Escaline was first synthesized and reported in the scientific literature by Benington, et al., in 1954, but was later re-examined in the laboratory of David E. Nichols who prepared a series of mescaline analogues that includes escaline, proscaline, and isoproscaline.
The effects of escaline were first described by Alexander Shulgin in his book PiHKAL: A Chemical Love Story. He lists the dosage range as 40mg to 60mg orally and describes the duration of action to be 8 - 12 hours.[1] Shulgin states that escaline “differs from mescaline in that the onset of action is quicker (within the first hour) and there is no nausea noted, but otherwise the time course, and much of the qualitative content, is quite similar.”. [2]
Contents
Chemistry
 |
This chemistry section is incomplete. You can help by adding to it. |
Escaline is the phenethylamine analog of 3C-E and the 4-ethoxy analog of mescaline.
Pharmacology
Escaline's agonist activity at the serotonin 5-HT2A receptor is known to be 5-8 times greater than that of mescaline. [3][4] The effects of this compound are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.
Subjective effects
The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.
Physical effects
- Spontaneous tactile sensations
- Stimulation
- Nausea
- Tactile enhancement
- Bodily control enhancement
- Pupil dilation
- Wakefulness
- Increased heart rate
- Muscle spasms
Cognitive effects
- Current mind state enhancement
- Thought acceleration
- Novelty enhancement
- Time distortion
- Déjà vu
- Personal bias suppression
- Conceptual thinking
- Immersion enhancement
- Memory suppression
- Thought loops
- Delusions
- Thought disorganization
- Suggestibility enhancement
- Laughter
- Mindfulness
- Feelings of interdependent opposites
- Spirituality enhancement
Visual effects
Enhancements
Distortions
- Drifting (melting, flowing, breathing and morphing)
- Tracers
- After images
- Symmetrical texture repetition
- Colour shifting
- Scenery slicing
Geometry
Hallucinatory states
- Transformations
- Internal hallucinations (autonomous entities; settings, sceneries, and landscapes; alterations in perspective and scenarios and plots)
- External hallucinations (autonomous entities; settings, sceneries, and landscapes; alterations in perspective and scenarios and plots)
Auditory effects
Toxicity and harm potential
Lethal dosage
The toxicity and long-term health effects of recreational escaline use do not seem to have been studied in any scientific context and the median lethal dose (LD50) is unknown. This is because escaline is a research chemical with very little history of human usage. Anecdotal evidence from those who have used escaline would suggest that there are little to no immediate or short-term negative health effects attributed to simply trying the drug at low to moderate doses or using it very sparingly. The validity of these statements, however, cannot be confirmed.
Tolerance and addiction potential
The addictive potential of escaline has not yet been formally studied, but anecdotal evidence would suggest that escaline is not physically addictive. Many users describe a self-regulating quality and commonly report a tolerance build up when using the drug consecutively many days in a row. A build up in tolerance may lead to weakened effects and a diminished experience; however, this effect is nearly non-existent when consumption periods are spaced 5-7 days apart.
Legal issues
 |
This legality section is a stub. As such, it likely contains incomplete or wrong information. You can help by expanding it. |
- United States: Escaline is unscheduled in the U.S., but may be illegal via the Federal Analog Act.
See also
External links
References
- ↑ www.erowid.org/library/books_online/pihkal/pihkal072.shtml | #72 E; ESCALINE
- ↑ https://www.erowid.org/archive/rhodium/chemistry/shulgin.pea.sar.hop.html | Psychotomimetic Drugs: Structure-Activity Relationships
- ↑ http://www.ncbi.nlm.nih.gov/pubmed/18666267 | Structure-activity relationships of phenylalkylamines as agonist ligands for 5-HT(2A) receptors.
- ↑ https://www.erowid.org/archive/rhodium/chemistry/shulgin.pea.sar.hop.html | Psychotomimetic Drugs: Structure-Activity Relationships
