Dehydroxyfluorafinil |
| Dehydroxyfluorafinil | |||||||||||||||||||||
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| The skeletal formula of fluorafinil | |||||||||||||||||||||
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| Chemical Nomenclature | |||||||||||||||||||||
| Common names | dehydroxyfluorafinil, deshydroxyl-fladrafinil, modafiendz | ||||||||||||||||||||
| Systematic name | 2-{[bis(4-fluorophenyl)methyl]sulfinyl}-N-methylacetamide | ||||||||||||||||||||
| Routes of Administration | |||||||||||||||||||||
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| Summary sheet: Dehydroxyfluorafinil |
Dehydroxyfluorafinil (also referred to as N-methyl dehydroxyfluorafinil or Modafiendz)[1] is an obscure nootropic of the benzhydryl class. It is closely related to adrafinil and modafinil and available through research chemical vendors under the brand name of "Modafiendz."[2]
Contents
Chemistry
N-methyl-dehydroxyfluorafinil, or 2-{[bis(4-fluorophenyl)methyl]sulfinyl}-N-methylacetamide is a synthetic molecule of the benzhydryl class. Benzhydryl compounds are comprised of two benzene rings attached to a single carbon molecule. Dehydroxyfluorafinil contains a fluorine group bound to each benzene ring at R4. It is classified as a sulphinyl benzhydryl molecule, as it also contains a sulphinyl group, a sulphur molecule double-bonded to an oxygen molecule, attached to the carbon of the benzhydryl group. From this sulphur group at R2, an acetamide group is bound at its free carbon through a carbonyl group to an amine group. This terminal amine group is N-substituted with a methyl chain. Dehydroxyfluorafinil is structurally similar to other benzhydrl stimulants modafinil and fluorafinil, it is the bis-fluoro-N-methyl analogue of modafinil. Dehydroxyfluorafinil is named for lacking the n substituted hydroxy group of fluorafinil, which is replaced by a methyl group in this molecule.
Dehydroxyfluorafinil is the bis-fluoro-N-methyl analogue to modafinil; it contains two fluorine groups bound to each benzene ring at carbon 4 and an OH- (hydroxy) group bound to the amine of modafinil.
Pharmacology
Although dehydroxyfluorafinil has not been formally studied, its parent compound (modafinil) has recently been shown to act as a reuptake inhibitor for the neurotransmitter dopamine, evidently leading to increased extraceullular concentrations of dopamine and dopaminergic neurotransmission. This essentially allows dopamine to accumulate and be reused, causing physically stimulating and motivating effects.
It can thus be reasoned that dehydroxyfluorafinil follows a comparable or identical mechanism of action as it is extremely similar in physical structure and almost indistinguishable in terms of the subjective effects it induces.
Subjective effects
The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.
Physical effects
- Stimulation - In terms of its effects on the user's physical energy levels, dehydroxyfluorafinil is commonly considered to be stimulating and energetic, but can be considered as much less stimulating when compared to amphetamine. This stimulation encourages physical movement and activities such as running, playing sports, socializing, and/or exercising. The particular style of stimulation which dehydroxyfluorafinil presents can result in jaw clenching, teeth grinding, or other involuntary movements comparable to that of traditional stimulants at high doses, but are manifested much less consistently and intensely when compared to amphetamine or cocaine.
- Dehydration - Dehydration and dry mouth commonly occur due to an increase in motivation to engage in physical activities as well as an increased sense of focus which causes one to forget to drink water.
- Headaches - In terms of physical discomfort, fluorafanil can cause headaches especially if dehydrated, if you have not eaten food or if you have been sitting in an awkward position for an extended period of time focused intensely on a task.
- Appetite suppression - The above components are also accompanied by a suppression of appetite which is usually much less intense in strength in comparison to the appetite suppression experienced with amphetamine.
- Diarrhea - Dehydroxyfluorafinil has the tendency to increase the frequency of bowel movements in certain individuals.
- Increased heart rate
- Dizziness
- Nausea
Cognitive effects
- Focus enhancement
- Wakefulness
- Thought acceleration
- Memory enhancement
- Motivation enhancement
- Emotion enhancement
- Anxiety
Toxicity and harm potential
The toxicity and long-term health effects of recreational dehydroxyfluorafinil use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because dehydroxyfluorafinil has very little history of human usage. Anecdotal evidence from people who have tried dehydroxyfluorafinil within the community suggest that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed). It is strongly recommended that one use harm reduction practices when using this drug.
Tolerance and addiction potential
The chronic use of dehydroxyfluorafinil can be considered as mildly addictive with a low potential for abuse and it does not seem to be capable of causing psychological dependence among certain users due to its lack of euphoria or recreational effects. If addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage.
Tolerance to many of the effects of dehydroxyfluorafinil develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). Dehydroxyfluorafinil presents cross-tolerance with all modafanil analogues, meaning that after the consumption of dehydroxyfluorafinil all modafanil analogues will have a reduced effect.
Dangerous interactions
Although many drugs are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
- 25x-NBOMe - Both the NBOMe series and this compound induce powerful stimulation and their interaction may cause severe side effects. These can include thought loops, seizures, increased blood pressure, vasoconstriction, increased heart rate, and heart failure (in extreme cases).
- Alcohol - It is dangerous to combine alcohol, a depressant, with stimulants due to the risk of excessive intoxication. Stimulants decrease the sedative effect of alcohol which is the main factor most people consider when determining their level of intoxication. Once the stimulant wears off, the effects of alcohol will be significantly increased, leading to intensified disinhibition as well as respiratory depression. If combined, one should strictly limit themselves to only drinking a certain amount of alcohol per hour.
- DXM - This combination may cause increased heart rate and panic attacks.
- MXE - Increased heart rate and blood pressure may occur.
- Tramadol - This combination can increase the risk of seizures.
- MDMA - The neurotoxic effects of MDMA may be increased when combined with other stimulants.
- MAOIs - This combination may increase the amount of neurotransmitters such as dopamine to dangerous or even fatal levels. Examples include syrian rue, banisteriopsis caapi, 2C-T-2, 2C-T-7, αMT, and some antidepressants.[3]
- Cocaine - This combination may increase strain on the heart.
Legal issues
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This legality section is a stub. As such, it likely contains incomplete or wrong information. You can help by expanding it. |
Dehydroxyfluorafinil is currently a grey area compound within most (if not all) parts of the world. This means that it is not known to be specifically illegal within any country, but people may still be charged for its possession under certain circumstances such as under analogue laws and with intent to sell or consume.
- United Kingdom - It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.[4]
See also
References
- ↑ http://www.chemspider.com/Chemical-Structure.29785194.html#synonymsTab
- ↑ http://lmgtfy.com/?q=modafiendz+buy
- ↑ Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity | http://bja.oxfordjournals.org/content/95/4/434
- ↑ Psychoactive Substances Act 2016 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/2016/2/contents/enacted
