2C-B

2C-B
The skeletal formula of 2C-B
Chemical Nomenclature
Common names	2C-B
Substitutive name	2,5-dimethoxy-4-bromophenethylamine
Systematic name	(2-(4-bromo-2,5-dimethoxyphenyl)ethanamine
Class Membership
Psychoactive class	Psychedelic
Chemical class	Phenethylamine
Routes of Administration
Oral Dosage WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation. Threshold 2 - 10 mg Light 10 - 20 mg Common 20 - 35 mg Strong 35 - 55 mg Heavy 55 mg + Duration Total 4 - 8 hours Onset 45 - 75 minutes Come up 15 - 30 minutes Peak 2 - 4 hours Offset 1 - 2 hours After effects 2 - 4 hours

Summary sheet: 2C-B

2C-B or 2,5-dimethoxy-4-bromophenethylamine is a substituted phenethylamine psychedelic drug of the 2C-x family. It was first synthesized by Alexander Shulgin in 1974. In Shulgin's book, PiHKAL, the dosage range is listed as 16–24 mg. 2C-B is sold as a white powder sometimes pressed in tablets or gel caps and is supposedly referred to on the street as 'Rusko', 'Spectrum', 'Venus', 'B's', 'CB's', or 'Nexus'. The drug is usually taken orally, but can also be insufflated or vaporized.

It first saw use among the psychiatric community as an aid during therapy. It was considered one of the best drugs for this purpose because of its short duration, relative absence of side effects, and comparably mild nature. Shortly after becoming popular in the medical community, it became popular recreationally.

2C-B was first sold commercially as an aphrodisiac under the trade name "Eros", which was manufactured by the German pharmaceutical company Drittewelle. For several years, it was available as tablets in Dutch smart shops under the name "Nexus". In modern times it is used as a recreational drug and an entheogen, rarely sold on the streets and almost exclusively obtained as a grey area research chemical through the use of online vendors.

Chemistry

General formula of phenethylamine molecule.

2C-B or 2,5-dimethoxy-4-bromophenethylamine is a substituted phenethylamine featuring a phenyl ring bound to an amino (NH₂) group through an ethyl chain. 2C-B contains methoxy functional groups CH₃O- attached to carbons R₂ and R₅ as well as a bromine attached to carbon R₄ of the phenyl ring. 2C-B belongs to the 2C family of phenethylamines which contain methoxy groups on the 2 and 5 positions of the benzene ring.

Pharmacology

Main article: Serotonergic psychedelic

Unlike most psychedelics, 2C-B has been shown to be a low efficacy serotonin 5-HT_2A receptor partial agonist or even full antagonist. This suggests that the 5-HT_2C receptor is primarily responsible for mediating the effects experienced by users of 2C-B. Research also suggests that 2C-B increases dopamine levels in the brains of rats which may contribute to its psychoactivity.

However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical effects

• Spontaneous tactile sensations - The "body high" of 2C-B is not necessarily one of the most intense, but is instead one of the most complex compared to other psychedelics, sharing components of MDMA, 2C-E, and LSD. This is first characterized by an intense soft warm glow that grows over the body and is capable of becoming extremely physically euphoric. This is most similar to MDMA and is consistently manifested throughout the experience. This is contrasted by an intensely pleasurable yet sharp, cold electric tingling sensation which moves up and down the body. This is most similar to LSD and is also consistently manifested throughout the trip. The final physical effect noticed throughout the experience is an intense and slightly uncomfortable, energetic pins and needles sensation that manifests itself in the form of a continuously shifting and tingling sensation that travels up and down the body in spontaneous waves. This is most similar to 2C-E and is not entirely consistent throughout the trip.
• Stimulation - In terms of its effects on the physical energy levels of the tripper, 2C-B is usually considered to be very energetic and stimulating in a fashion that is quite comparable to that of MDMA.
• Nausea - Mild to extreme nausea is reported when consumed in moderate to high dosages and either passes once the tripper has vomited or gradually fades by itself as the peak sets in.
• Bodily control enhancement
• Increased blood pressure
• Increased heart rate
• Physical euphoria
• Pupil dilation
• Tactile enhancement
• Teeth grinding - This component can be considered to be less intense when compared with that of MDMA.

Cognitive effects

The cognitive effects of 2C-B are often described by many as both insightful and relatively normal in their thought processes even at moderate to high dosages.

The total sum of these cognitive components regardless of the setting generally includes:

• Empathy, love and sociability enhancement - These feelings of sociability, love and empathy are a little weaker and less sharp than those found on substances such as MDMA but still prove stronger and more consistent than other psychedelics of any class. This is capable of providing long-lasting therapeutic effects.
• Analysis enhancement - This effect is consistently manifested only in the context of a non-social setting in which the user is alone and is introspection dominant.
• Conceptual thinking
• Delusions
• Emotion enhancement
• Feelings of interdependent opposites
• Feelings of self-design
• Immersion enhancement
• Increased music appreciation
• Increased libido
• Memory suppression
  • Ego death
• Novelty enhancement
• Personal bias suppression
• Rejuvenation
• Thought acceleration
• Thought connectivity
• Time distortion
• Wakefulness

Visual effects

Enhancements

• Colour enhancement
• Pattern recognition enhancement
• Visual acuity enhancement

Distortions

• Drifting (melting, flowing, breathing and morphing) - In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion, static in appearance and unrealistic/cartoon-like in style.
• After images
• Colour shifting
• Depth perception distortions
• Recursion
• Scenery slicing
• Symmetrical texture repetition
• Tracers
• Visual haze

Geometry

The visual geometry that is present throughout this trip is more similar in appearance to that of LSD than that of 2C-E, psilocin, or ayahuasca. They can be comprehensively described as unstructured in their organization, algorithmic in geometric style, intricate in complexity, large in size, fast and smooth in motion, colourful in scheme, glossy in colour, sharp in their edges and angular in their corners. They seem high in algorithmic visuals such as fractals and at higher dosages are significantly more likely to result in states of level 8A visual geometry over level 8B.

Hallucinatory states

Like LSD, while 2C-B is capable of producing a full range of low and high level hallucinatory states, this is extremely rare and inconsistent at higher levels but common at lower and generally includes the following effects:

• Transformations
• Internal hallucinations (autonomous entities; settings, sceneries, and landscapes; alterations in perspective and scenarios and plots) - Although 2C-B is technically capable producing of hallucinatory states in a fashion that is on par with psilocin or DMT in its vividness and intensity, in comparison, these effects are extremely rare and inconsistent. Whilst traditional psychedelics such as LSA, ayahuasca and mescaline will induce internal hallucinations near consistently at level 5 geometry and above, 2C-B will for most go straight into Level 8A visual geometry. This lack of consistently induced hallucinatory breakthroughs means that for some, 2C-B is simply not as deep of an experience as certain other psychedelics.

Auditory effects

• Enhancements
• Distortions
• Hallucinations

Multi-sensory effects

• Synaesthesia

Toxicity and harm potential

Main article: Responsible use § Hallucinogens

The toxicity and long-term health effects of recreational 2C-B use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. Anecdotal evidence from people who have tried 2C-B within the psychedelic community suggests that there are no negative health effects attributed to trying this drug, but nothing can be completely guaranteed.

It is strongly recommended that one use harm reduction practices when using this drug.

Lethal dosage

There is no current data for the LD₅₀ of 2C-B, but it is thought to be considerably higher than the active dosage. Alexander Shulgin reported a 100 mg oral dose taken without apparent harm.

Tolerance and addiction potential

2C-B is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of 2C-B are not built almost immediately after ingestion as with other psychedelics. There are many anecdotal reports of people ingesting this substance many days in a row with no immediate tolerance build up.

Legal issues

• Australia: Possession, production and sale is illegal.
• Belgium: Possession, production and sale is illegal.
• Brazil: Possession, production and sale is illegal.
• The EU: 2C-B is a Schedule II drug.
• Canada: 2C-B is a Schedule III drug.
• Italy:2C-B is Schedule I (tabella I)
• Estonia: 2C-B is a Schedule I drug.
• Finland: Possession, production and sale is illegal.
• Japan: Possession, production and sale is illegal.
• The Netherlands: Possession, production and sale is illegal.
• Latvia: 2C-B is a Schedule I controlled substance.
• Norway: 2C-B is a Schedule II drug.
• Poland: 2C-B is a Schedule I drug.
• Russia: Possession, production and sale is illegal.
• Spain: 2C-B is a Category 2 drug.
• Sweden: 2C-B is a Schedule I drug.
• Switzerland: Possession, production and sale is illegal.
• UK: 2C-B is a Class A drug.
• USA: 2C-B is a Schedule I drug.

Experience reports

Anecdotal reports which describe this compound within our experience index include:

• Experience:150mg MDMA + 20mg 2C-B - I designed it this way myself

Additional experience reports can be found here:

• Erowid Experience Vaults: 2C-B

See also

• Responsible use
• Psychedelics
• Phenethylamines
• 2C-B-FLY
• 2C-x
• 2C-C
• 2C-D
• 2C-E

External links

• 2C-B (Wikipedia)
• 2C-B (Erowid)
• 2C-B experiences (Erowid)
• 2C-B (Tripsit)
• 2C-B (Bluelight)
• 2C-B (PiHKAL / Isomerdesign)
• 2C-B (Disregard Everything I Say)