Methallylescaline

Methallylescaline
Chemical Nomenclature
Common names	MAL, Methallylescaline
Systematic name	2-{3,5-dimethoxy-4-[(2-methylprop-2-en-1-yl)oxy]phenyl}ethanamine
Class Membership
Psychoactive class	Psychedelic
Chemical class	Phenethylamine
Routes of Administration
Oral Dosage WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy. Threshold 10 - 15 mg Light 15 - 25 mg Common 25 - 40 mg Strong 40 - 60 mg Heavy 60 mg + Duration Total 6 - 12 hours Onset 20 - 60 minutes After effects 3 - 5 hours

Summary sheet: Methallylescaline

Methallylescaline, MAL or 4-methallyloxy-3,5-dimethoxyphenethylamine is a psychedelic drug and entheogen of the phenethylamine class of compounds. It is relatively uncommon and has little to no history of human usage. Very little data exists about the pharmacological properties, metabolism, and toxicity of the drug.

The effects of this compound were first described by Alexander Shulgin in his book PiHKAL: A Chemical Love Story. He lists the dosage range as 40mg to 60mg orally and describes the duration of action to be 8 - 12 hours.

Chemistry

Methallylescaline, or 4-methallyloxy-3,5-dimethoxyphenethylamine, is a substituted phenethylamine featuring a phenyl ring bound to an amino (NH₂) group through an ethyl chain. Methallylescaline contains two methoxy functional groups (CH₃O-) which are attached to carbons R₃ and R₅ of the phenyl ring.

Methallylescaline is substituted at R₄ with a methallyloxy chain. This three carbon chain consists of a R₂ methyl substituted allyl group with a double bond on the terminal carbon. This chain is connected to the phenyl ring at R₄ through an ether (oxygen) bridge.

Pharmacology

Main article: Serotonergic psychedelic

Methallylescaline likely acts as a 5-HT_2A partial agonist. The psychedelic effects are believed to come from methallylescaline's efficacy at the 5-HT_2A receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Subjective effects

This subjective effect breakdown is a stub. As such, it may contain incomplete or wrong information and is still in progress. You can help by expanding it.

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical effects

• Spontaneous tactile sensations
• Stimulation
• Nausea
• Tactile enhancement
• Bodily control enhancement
• Pupil dilation
• Wakefulness

Cognitive effects

• Emotion enhancement
• Thought acceleration
• Novelty enhancement
• Time distortion
• Analysis enhancement
• Personal bias suppression
• Conceptual thinking
• Immersion enhancement
• Memory suppression
  • Ego death
• Thought loops
• Delusions
• Thought disorganization

Visual effects

Enhancements

• Acuity enhancement
• Colour enhancement
• Pattern recognition enhancement

Distortions

• Drifting (melting, flowing, breathing and morphing)
• Tracers
• After images
• Symmetrical texture repetition
• Colour shifting
• Scenery slicing

Hallucinatory states

• Transformations
• Internal hallucinations (autonomous entities; settings, sceneries, and landscapes; alterations in perspective and scenarios and plots)

Auditory effects

• Enhancements
• Distortions
• Hallucinations

Toxicity and harm potential

Main articles: Research chemicals § Toxicity and harm potential & Responsible use § Hallucinogens

The toxicity and long-term health effects of recreational methallylescaline use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because methallylescaline is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried methallylescaline suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption. It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

Methallylescaline is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of methallylescaline are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). Methallylescaline presents cross-tolerance with all psychedelics, meaning that after the consumption of methallylescaline all psychedelics will have a reduced effect.

Legal issues

This legality section is a stub. As such, it likely contains incomplete or wrong information. You can help by expanding it.

• United Kingdom - It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.
• United States - Methallylescaline is unscheduled in the U.S., but may be illegal via the Federal Analog Act.

See also

• Responsible use
• Mescaline
• Phenethylamine
• Hallucinogen

External links

• Methallylescaline (PiHKAL)
• Methallylescaline (Wikipedia)
• Methallylescaline experiences (Erowid)
• Methallylescaline (Tripsit)
• Methallylescaline (Bluelight)