2C-E
From PsychonautWiki
Jump to: navigation, search
2C-E
The skeletal formula of 2C-E.
2C-E.png
2CE3d.gif
Chemical Nomenclature
Common names 2C-E
Substitutive name 2,5-dimethoxy-4-ethylphenethylamine
Systematic name 2-(4-Ethyl-2,5-dimethoxyphenyl)ethanamine
Class Membership
Psychoactive class Psychedelic
Chemical class Phenethylamine
Routes of Administration



Oral
Dosage
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.
DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Threshold 2 - 5 mg
Light 5 - 10 mg
Common 10 - 15 mg
Strong 15 - 30 mg
Heavy 30 mg +
Duration
Total 4 - 9 hours
Onset 20 - 90 minutes
Come up 15 - 30 minutes
Peak 3 - 7 hours
Offset 1 - 2 hours
After effects 2 - 4 hours



Insufflated
Dosage
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.
DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Light 1 - 4 mg
Common 5 - 7 mg
Strong 8 - 14 mg
Heavy 14 mg +
Duration
Onset 1 - 2 minutes
Peak 2 - 4 hours
Offset 1 - 2 hours
After effects 2 - 4 hours






Summary sheet: 2C-E

2C-E or 2,5-dimethoxy-4-ethylphenethylamine is a psychedelic phenethylamine of the 2C-x family. It was first synthesized by Alexander Shulgin.

2C-E is a highly dose sensitive psychedelic known for its strong visuals and intense body load. Many reports also indicate that the effects of this chemical may be overly intense for those who are not already experienced with psychedelics.

Chemistry

General formula of phenethylamine molecule.

2C-E or 2,5-dimethoxy-4-ethylphenethylamine is a substituted phenethylamine featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain. 2C-E contains methoxy functional groups CH3O- attached to carbons R2 and R5 and an ethyl chain bound to carbon R4 of the phenyl ring. 2C-E belongs to the 2C family of phenethylamines which contain methoxy groups on the 2 and 5 positions of the benzene ring. [1]

Pharmacology

Main article: Serotonergic psychedelic

2C-E's psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical effects

  • Spontaneous tactile sensations - The "body high" of 2C-E is manifested as one of the most proportionally intense in comparison to almost all of the classical psychedelics. This is something which is only beaten in terms of its overwhelming forcefulness by high dose AMT and 5-MeO-DMT experiences. The sensation itself can be described as an intense and slightly uncomfortable energetic pins and needles sensation that constantly encompasses a person’s entire body. It is usually felt over every square inch of the skin but occasionally manifests itself in the form of a continuously shifting tingling sensation that travels up and down the body in spontaneous waves. Alongside of this, many users commonly report that the "body high" can be particularly uncomfortable and sometimes accompanied by urges to shift the position of one's body into prolonged tensing of unusual combinations of muscle groups.
  • Stimulation - In terms of its effects on the physical energy levels of the tripper, 2C-E is usually considered to be very energetic and stimulating in a fashion that is quite comparable to that of MDMA.
  • Bodily control enhancement
  • Tactile enhancement
  • Nausea - Mild to extreme nausea is consistently reported when consumed in moderate to high dosages and either passes once the person has vomited or gradually fades by itself as the peak sets in.
  • Temperature regulation suppression
  • Increased heart rate
  • Increased blood pressure
  • Pupil dilation

Cognitive effects

The head space of 2C-E is described by many as one which is both insightful and relatively normal in its thought processes even at moderate to high dosages.

The total sum of these cognitive components regardless of the setting generally includes:

Visual effects

Enhancements

Distortions

Geometry

The visual geometry that is present throughout this trip can be described as more similar in appearance to that of 4-AcO-DMT or ayahuasca than that of LSD, 2C-B or 2C-I. They can be comprehensively described as structured in their organization, organic in geometric style, intricate in complexity, large in size, fast and smooth in motion, colourful in scheme, glossy in colour, sharp in their edges and equally rounded and angular in their corners. It gives off a contradictory natural and synthetic feel that at higher dosages are significantly more likely to result in states of Level 8B visual geometry over Level 8A.

Hallucinatory states

2C-E produces a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. This holds particularly true in comparison to other substances within the the phenethylamine family. These effects include:

  • Transformations
  • Internal hallucinations (autonomous entities; settings, sceneries, and landscapes; alterations in perspective and scenarios and plots) - In comparison to other psychedelics such as LSD, 2C-E is extremely high in hallucinations embedded within visual geometry. This particular effect commonly contains hallucinations with scenarios, settings, concepts and autonomous entity contact. They are more common within dark environments and can be described as internal in their manifestation, lucid in believability, interactive in style and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.

Auditory effects

Multi-sensory effects

Toxicity and harm potential

Lolol.pngMain articles: Research chemicals § Toxicity and harm potential & Responsible use § Hallucinogens

The toxicity and long-term health effects of recreational 2C-E use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 2C-E is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried 2C-E suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

2C-E is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of 2C-E are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 2C-E presents cross-tolerance with all psychedelics, meaning that after the consumption of 2C-E all psychedelics will have a reduced effect.

Legal issues

  • Denmark: 2C-E is a Schedule I drug.
  • Finland: The possession, production and sale is illegal.
  • Israel: Possession, production and sale is illegal.
  • New Zealand: 2C-E is a Class C drug.
  • Sweden: 2C-E is a Schedule I drug.
  • Switzerland: Possession, production and sale is illegal.
  • UK: 2C-E is a Class A drug.
  • USA: 2C-E is a Schedule I drug. [2]
  • Germany: On December 13, 2014 2C-E was added to the controlled substance act ("BtMG"), making it illegal to produce, sell or possess.[3]
  • Latvia: 2C-E is a Schedule I controlled substance.[4]

Experience reports

Anecdotal reports which describe this compound within our experience index include:

Additional experience reports can be found here:

See also

External links

References

  1. ↑ http://isomerdesign.com/PiHKAL/read.php?id=24
  2. ↑ http://www.justice.gov/ola/views-letters/112/093011-ltr-re-hr1254-synthetic-drug-control-act-2011.pdf
  3. ↑ Achtundzwanzigste Verordnung zur Änderung betäubungsmittelrechtlicher Vorschriften (28. BtMÄndV)| http://www.buzer.de/gesetz/11392/a189949.htm
  4. ↑ Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem (2,5-Dimetoksifeniletānamīni) | http://likumi.lv/doc.php?id=121086
Retrieved from ‘https://psychonautwiki.org/w/index.php?title=2C-E&oldid=76499’