2C-I

2C-I
The skeletal formula of 2C-I
Chemical Nomenclature
Common names	2C-I
Substitutive name	2,5-Dimethoxy-4-iodophenethylamine
Class Membership
Psychoactive class	Psychedelic, Entactogen
Chemical class	Phenethylamine
Routes of Administration
Oral Dosage WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy. Threshold 2 - 5 mg Light 5 - 15 mg Common 10 - 25 mg Strong 20 - 30 mg Heavy 30 mg + Duration Total 5 - 10 hours Onset 20 - 90 minutes Come up 20 - 30 minutes Peak 3 - 7 hours Offset 1 - 2 hours After effects 2 - 4 hours

Summary sheet: 2C-I

2C-I or 2,5-dimethoxy-4-iodophenethylamine is a psychedelic phenethylamine of the 2C-x family. It was first synthesized by Alexander Shulgin in the 1991 book PiHKAL: A Chemical Love Story. The drug is used recreationally for its psychedelic and entactogenic effects and has been explored as a potential stimulant nootropic in doses between 1-8mg.

2C-I is sometimes confused for the analog 25I-NBOMe and is commonly sold in its hydrochloride salt form which is a fluffy, sparkling, white powder which is sometimes pressed into tablet form.

Chemistry

General formula of phenethylamine molecule

2,5-dimethoxy-4-iodophenethylamine is a substituted phenethylamine featuring a phenyl ring bound to an amino (NH₂) group through an ethyl chain. 2C-I contains methoxy functional groups CH₃O- attached to carbons R₂ and R₅ as well as an iodine attached to carbon R₄ of the phenyl ring. 2C-I belongs to the 2C family of phenethylamines which contain methoxy groups on the 2 and 5 positions of the benzene ring.

Pharmacology

Main article: Serotonergic psychedelic

2C-I's psychedelic effects are believed to come from its efficacy at the 5-HT_2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical effects

• Spontaneous tactile sensations - The "body high" of 2C-I is manifested as one of the most proportionally intense in comparison to almost all of the classical psychedelics. The sensation itself can be described as an intense and slightly uncomfortable energetic pins and needles sensation that constantly encompasses a person’s entire body. It is usually felt over every square inch of the skin but occasionally manifests itself in the form of a continuously shifting, tingling sensation that travels up and down the body in spontaneous waves. Alongside of this, many users commonly report that the "body high" can be particularly uncomfortable and sometimes accompanied by dysphoric aches and urges to shift the position of one's body and prolonged tensing of unusual combinations of muscle groups.
• Bodily control enhancement
• Increased heart rate
• Nausea - Mild to extreme nausea is consistently reported when consumed in moderate to high doses and either passes once the tripper has vomited or gradually fades by itself as the peak sets in.
• Euphoria - Feelings of frequent but unpredictable rushes of warm physical euphoria are extremely common and very pleasurable. These move from the top of the head downwards before enveloping one's whole body.
• Pupil dilation
• Stimulation - In terms of its effects on the physical energy levels of the tripper, 2C-I is usually considered to be very energetic and stimulating in a fashion that is quite comparable to that of MDMA although it is encouraged instead of forced.
• Tactile enhancement
• Temperature regulation suppression

Cognitive effects

The head space of 2C-I is described by many as one which is relatively normal in its thought processes even at moderate to high doses. It is often said to lack insight when compared to that of 2C-E, 2C-B and LSD.

The total sum of these cognitive components regardless of the setting generally includes:

• Analysis enhancement
• Emotion enhancement
• Empathy, love and sociability enhancement - This component is consistently manifested only in the context of social settings in which one is within the company of others. These feelings of sociability, love and empathy are a little weaker and less sharp than those found on substances such as MDMA and 2C-B but still prove strong enough to provide long-lasting therapeutic effects.
• Immersion enhancement
• Increased libido
• Increased music appreciation
• Memory suppression
  • Ego death
• Novelty enhancement
• Time distortion
• Unity and interconnectedness
• Wakefulness

Visual effects

Enhancements

• Acuity enhancement
• Colour enhancement
• Pattern recognition enhancement

Distortions

• Drifting (melting, flowing, breathing and morphing) - In comparison to other psychedelics, this effect can be described as simplistic and bland in detail, slow and smooth but sometimes jittery in motion, static in appearance and unrealistic/cartoon-like in style.
• Tracers
• Symmetrical texture repetition
• Colour shifting
• Scenery slicing
• External geometry

Geometry

The visual geometry that is present throughout this trip can be described as more similar in appearance to that of LSD or 2C-B than that of 2C-E, psilocin, or ayahuasca although it is much more bland and less detailed. They can be comprehensively described as unstructured in their organization, algorithmic in geometric style, intricate in complexity, large in size, fast and smooth in motion, colourful in scheme, glossy in colour, both soft and sharp in their edges as well as equally rounded and angular in their corners. They seem high in algorithmic visuals such as fractals and at higher doses are significantly more likely to result in states of level 8A visual geometry over level 8B.

Hallucinatory states

Like LSD, while 2C-I is capable of producing a full range of low and high level hallucinatory states, this is extremely rare and inconsistent at higher levels but common at lower and generally includes the following effects:

• Transformations
• Internal hallucinations (autonomous entities; settings, sceneries, and landscapes; alterations in perspective and scenarios and plots) - Although 2C-I is technically capable of producing hallucinatory states in a fashion that is on par with psilocin or DMT in its vividness and intensity, in comparison, these effects are extremely rare and inconsistent. Whilst traditional psychedelics such as LSA, ayahuasca and mescaline will induce internal hallucinations near consistently at level 5 geometry and above, 2C-I hallucinations will not extend beyond imagery and higher doses will for most simply go straight into level 8A visual geometry. This lack of consistently induced hallucinatory breakthroughs means that, for most, 2C-I is simply not as deep of an experience as certain other psychedelics.
• External hallucinations (autonomous entities; settings, sceneries, and landscapes; alterations in perspective and scenarios and plots)

Auditory effects

• Enhancements
• Distortions
• Hallucinations

Multi-sensory effects

• Synaesthesia

Toxicity and harm potential

Main articles: Research chemicals § Toxicity and harm potential & Responsible use § Hallucinogens

The toxicity and long-term health effects of recreational 2C-I use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 2C-I is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried 2C-I suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

2C-I is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of 2C-I are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 2C-I presents cross-tolerance with all psychedelics, meaning that after the consumption of 2C-I all psychedelics will have a reduced effect.

Legal issues

• European Union: In December 2003, the European Council issued a binding order compelling all EU member states to ban 2C-I within three months.
• Denmark: It is a controlled substance.
• Germany: It is a controlled substance.
• Greece: It is a controlled substance.
• Ireland: The drug is a controlled substance.
• Italy: It is a controlled substance.
• Latvia: 2C-I is a Schedule I controlled substance.
• Netherlands: It is a controlled substance.
• Poland: It is a controlled substance.
• Sweden: Sveriges riksdag added 2C-I to Schedule I ("substances, plant materials and fungi which normally do not have medical use") as a narcotic in Sweden as of March 16, 2004.
• United Kingdom: It is controlled as a Class A substance.
• U.S.: As of July 9, 2012, 2C-I is a Schedule I substance in the U.S. under the Synthetic Drug Abuse Prevention Act of 2012, making possession, distribution and manufacture illegal.

See also

• Responsible use
• Psychedelics
• Phenethylamines
• 2C-x
• 25I-NBOMe

External links

• 2C-I (Wikipedia)
• 2C-I (Erowid)
• 2C-I experiences (Erowid)
• 2C-I (PiHKAL)
• 2C-I (Bluelight)
• 2C-I (TripSit)