ALD-52 |
| ALD-52 | |||||||||||||||||||||||||||||
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| The skeletal formula of ALD-52 | |||||||||||||||||||||||||||||
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| Chemical Nomenclature | |||||||||||||||||||||||||||||
| Common names | Orange Sunshine | ||||||||||||||||||||||||||||
| Substitutive name | ALD-52 | ||||||||||||||||||||||||||||
| Systematic name | (6aR,9R)-4-acetyl-N,N-diethyl-7-methyl-4,6,6a,7,8,9-hexahydroindolo-[4,3-fg]-quinoline-9-carboxamide | ||||||||||||||||||||||||||||
| Class Membership | |||||||||||||||||||||||||||||
| Psychoactive class | Psychedelic | ||||||||||||||||||||||||||||
| Chemical class | Lysergamide | ||||||||||||||||||||||||||||
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| Summary sheet: ALD-52 |
ALD-52, also known as 1-acetyl-LSD, is a hallucinogenic psychedelic drug of the lysergamide family. It was originally discovered by Albert Hofmann, but was not widely studied until psychedelics rose in popularity in the 1960s.
This substance has little to no history of human usage. It has not been reported upon within any formal scientific literature and is almost entirely unknown by both the academics and public. However, its structural similarity to LSD suggests an extremely similar effect profile. Due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is purely based on its structure and subjective effect similarities to other lysergamides.
In the book TiHKAL, which discussed LSD, Alexander Shulgin touched briefly on the subject of ALD-52. His writings are vague, second hand accounts which state that doses in the 50-175 µg range have resulted in various effects. He found that there was less visual distortion than with LSD and it seemed to produce less anxiety and tenseness. He also states that it is somewhat less potent than LSD. Another informant claimed it was more effective in increasing blood pressure and another informant could not tell the two drugs apart.[1]
Contents
Chemistry
ALD-52, or D-1-Acetyl lysergic acid diethylamide, is a semi-synthethic molecule of the lysergamide famiy. ALD-52 is a substituted derivative of lysergic acid. ALD-52's structure contains four rings, a bicyclic hexahydroindole fused to a bicyclic quinoline group. This core struture of ALD-52 is an indole derivative, and has tryptamine and phenethylamine groups embedded within it. ALD-52 contains a N,N-diethylcarboxamide functional group bound to R8 of the chemical structure. It is additionally substituted at carbon 6 with a methyl group.
ALD-52 is homologous to 1P-LSD, which contains an propionyl group bound to CH3-CO-R instead of the acetyl group bound to the same location.
Pharmacology
ALD-52 likely acts as a 5-HT2A partial agonist. The psychedelic effects are believed to come from ALD-52's efficacy at the 5-HT2A receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.
Subjective effects
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This subjective effect breakdown is a stub. As such, it may contain incomplete or wrong information and is still in progress. You can help by expanding it. |
The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.
Cognitive effects
In comparison to other lysergamides such as LSD and 1P-LSD, ALD-52 is less stimulating and is associated with a more relaxed mental state.
The most prominent of these cognitive effects generally include:
- Analysis enhancement
- Conceptual thinking
- Delusions
- Déjà vu
- Emotion enhancement
- Immersion enhancement
- Laughter
- Memory suppression
- Novelty enhancement
- Personal bias suppression
- Spirituality enhancement
- Thought acceleration
- Thought disorganization
- Thought loops
- Time distortion
- Unity and interconnectedness
- Wakefulness
Visual Effects
Enhancements
Distortions
- Drifting (melting, breathing, morphing and flowing) - In comparison to other psychedelics such as LSD, the distortions produced by ALD-52 can appear much more sharp and life-like.
- After images
- Colour shifting
- Depth perception distortions
- Perspective distortions
- Scenery slicing
- Symmetrical texture repetition
- Tracers
Geometry
The geometry of ALD-52 is very similar to that of its close relative LSD. The geometry of ALD-52 is suspected (but not confirmed) to lead to level 8A geometry (similar to LSD).
Hallucinatory states
- Transformations
- Internal hallucinations (autonomous entities; settings, sceneries, and landscapes; alterations in perspective and scenarios and plots)
Auditory effects
Toxicity and harm potential
The toxicity and long-term health effects of recreational ALD-52 use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because ALD-52 is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried ALD-52 suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
It is strongly recommended that one use harm reduction practices when using this drug.
Tolerance and addiction potential
ALD-52 is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.
Tolerance to the effects of ALD-52 are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). ALD-52 presents cross-tolerance with all psychedelics, meaning that after the consumption of ALD-52 all psychedelics will have a reduced effect.
Legal issues
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This legality section is a stub. As such, it likely contains incomplete or wrong information. You can help by expanding it. |
- U.K. - On June 10, 2014 the U.K. Advisory Council on the Misuse of Drugs (ACMD) recommended that ALD-52 be specifically named in the U.K. Misuse of Drugs Act as a class A drug despite not identifying it as ever having been sold or any harm associated with its use. The U.K. Home Office accepted this advice and announced a ban of the substance to be enacted on January 6, 2015 as part of the Misuse of Drugs Act 1971 (Amendment) (No. 2) Order 2014.[2]
- Latvia - ALD-52 is illegal in Latvia. Although it isn't officially scheduled, it is controlled as an LSD structural analog due to an amendment made on June 1th, 2015.[3]
See also
External links
References
- ↑ Erowid Online Books: "TiHKAL" - #26. LSD-25 | https://www.erowid.org/library/books_online/tihkal/tihkal26.shtml
- ↑ Update of the generic definition for tryptamines | https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/318693/UpdateGenericDefinitionTryptamines.pdf
- ↑ Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem (2.4.punkts) | http://likumi.lv/doc.php?id=121086
