1P-LSD

1P-LSD
The skeletal formula of 1P-LSD
Chemical Nomenclature
Common names	1P-LSD
Substitutive name	1-propionyl-lysergic acid diethylamide
Systematic name	(6aR,9R)-4-propionyl-N,N-diethyl-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide
Class Membership
Psychoactive class	Psychedelic
Chemical class	Lysergamide
Routes of Administration
Oral Dosage WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. Threshold < 20 µg Light 25 - 75 µg Common 50 - 150 µg Strong 150 - 400 µg Heavy 400 µg + Duration Total 8 - 10 hours Onset 20 - 60 minutes Come up 15 - 30 minutes Peak 2 - 5 hours Offset 2 - 4 hours Afterglow 2 hours +

Summary sheet: 1P-LSD

1-propionyl-lysergic acid diethylamide (abbreviated as 1P-LSD or 1P-LAD) is a hallucinogenic psychedelic drug of the lysergamide family.

This substance has little to no history of human usage. It has not been reported upon within any formal scientific literature and is almost entirely unknown by both the academics and public. However, its structural similarity to LSD and ALD-52 suggests an extremely similar effect profile. Due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is purely based on its structure and subjective effect similarities to other lysergamides.

Over the first few months of 2015, it began to be marketed as a legal alternative to LSZ, AL-LAD and LSD through online research chemical vendors which are currently selling the compound in the form of freely available blotter sheet tabs. It is usually marketed as a research chemical, which means that it is sold legally but not meant for human consumption.

Chemistry

1P-LSD is a molecule of the lysergamide family. It is analogous to LSD and is named for the propionyl group bound to the nitrogen of the polycyclic indole group of LSD. Propionyl consists of the carbonyl chain CH3CH2-CO-R bound to an amino group. 1P-LSD is homologous to ALD-52, which contains an acetyl group bound to CH3-CO-R instead of the propionyl group bound to the same location. The structure of 1P-LSD contains a polycylic group featuring a bicyclic hexahydroindole bound to a bicyclic quinoline group. At carbon 9 of the quinoline, a N,N-diethyl carboxamide is bound.

Pharmacology

Main article: Serotonergic psychedelic

1P-LSD likely acts as a 5-HT_2A partial agonist. The psychedelic effects are believed to come from 1P-LSD's efficacy at the 5-HT_2A receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

It has been theorized that 1P-LSD may be a prodrug to LSD. While 1P-LSD shows only 38% the potency of LSD in mice, LSD is detected via LC-MS when 1P-LSD is incubated in human serum, meaning 1P-LSD not only acts as a prodrug for LSD, but is also a directly acting serotonin receptor agonist in its own right.

Subjective effects

The effects of 1P-LSD are almost identical to that of its close structural relative LSD with the differences being so minuscule that they are almost negligible and essentially virtually indistinguishable from one another. In comparison to other psychedelics such as psilocin, LSA and ayahuasca, 1P-LSD is significantly more stimulating and fast-paced in terms of the specific style of its physical and cognitive effects.

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical effects

• Spontaneous tactile sensations - The "body high" of 1P-LSD can be described as proportionally very intense in comparison to its accompanying visual and cognitive effects. It behaves as a euphoric, fast-moving, sharp and location specific tingling sensation. For some, it is manifested spontaneously at different unpredictable points throughout the trip, but for most it maintains a steady presence that rises with the onset and hits its limit once the peak has been reached. At moderate to high doses of 1P-LSD, this sensation will usually hit its highest level and become so overwhelming that people may find themselves writhing on the floor in complete pleasure.
• Stimulation - In terms of its effects on the physical energy levels of the tripper, 1P-LSD is usually considered to be very energetic and stimulating without being forced. For example, when taken in any environment it will usually encourage physical activities such as running, walking, climbing or dancing. In comparison, other more commonly used psychedelics such as psilocin are generally sedating and relaxed.
• Nausea - Mild nausea is occasionally reported when consumed in moderate to high doses and either passes instantly once the tripper has vomited or gradually fades by itself as the peak sets in.
• Tactile enhancement
• Bodily control enhancement
• Increased heart rate
• Pupil dilation

Cognitive effects

• Current mind state enhancement
• Thought acceleration
• Novelty enhancement
• Immersion enhancement
• Time distortion
• Analysis enhancement
• Personal bias suppression
• Conceptual thinking
• Memory suppression
  • Ego death
• Mindfulness
• Thought loops
• Feelings of interdependent opposites
• Delusions
• Unity and interconnectedness
• Feelings of self-design
• Spirituality enhancement
• Thought disorganization
• Wakefulness
• Creativity enhancement

Visual effects

Enhancements

• Visual acuity enhancement
• Colour enhancement
• Pattern recognition enhancement

Distortions

• Drifting (melting, breathing, morphing and flowing) - In comparison to other psychedelics, this effect can be described as highly detailed and cartoon-like in its appearance. The distortions are slow and smooth in motion and fleeting in appearance.
• Tracers
• Depth perception distortions
• Symmetrical texture repetition
• Colour shifting
• Perspective distortions

Geometry

The visual geometry that is present throughout this trip can be described as more similar in appearance to that of 2C-B or 2C-I than psilocin, LSA or DMT. It can be comprehensively described through its variations as primarily intricate in complexity, algorithmic in form, unstructured in organization, brightly lit, colourful in scheme, synthetic in feel, multicoloured in scheme, flat in shading, sharp in edges, large in size, fast in speed, smooth in motion, angular in its corners, non-immersive in depth and consistent in intensity.

In the case of higher level geometry, this substance is level 8A dominant but is also capable of inducing 8B Geometry under the right circumstances.

Hallucinatory states

• Transformations
• Internal hallucinations (autonomous entities; settings, sceneries, and landscapes; alterations in perspective and scenarios and plots) - Although 1P-LSD is technically capable of producing hallucinatory states in a fashion that is on par with psilocin or DMT in its vividness and intensity, these effects are rarer and more inconsistent in comparison. While traditional psychedelics such as LSA, ayahuasca and mescaline will induce internal hallucinations near consistently at level 5 geometry and above, 1P-LSD will for most simply go straight into level 8A visual geometry. This lack of consistently induced hallucinatory breakthroughs means that, for most, 1P-LSD is not quite as deep of an experience as certain other psychedelics. On the occasion that they are induced, however, they can be comprehensively described in terms of their variations as lucid in believability, interactive in style, new experiences in content, autonomous in controllability and geometry-based in appearance.
• External hallucinations (autonomous entities; settings, sceneries, and landscapes; alterations in perspective and scenarios and plots)

Auditory effects

• Enhancements
• Distortions
• Hallucinations

Toxicity and harm potential

The toxicity and long-term health effects of recreational 1P-LSD use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 1P-LSD is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychedelic community who have tried 1P-LSD suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses or using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

Tolerance and addiction potential

1P-LSD is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of 1P-LSD are built almost immediately after ingestion. After that it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). Note that 1P-LSD presents cross-tolerance with all psychedelics, meaning that after the consumption of 1P-LSD all psychedelics will have a reduced effect.

Legal issues

1P-LSD is currently a grey area compound within many parts of the world. This means that it is not known to be specifically illegal within most countries, but people may still be charged for its possession under certain circumstances such as under analogue laws and with the intent to sell or consume.

• USA - Since 1P-LSD is a prodrug of LSD, it would likely be illegal in the United States under the Federal Analogue Act.
• Switzerland - 1P-LSD is illegal in Switzerland as of December 2015.
• Latvia - 1P-LSD is illegal in Latvia, although it isn't included into schedules of controlled substances, it is controlled as the LSD structural analog, amendment came into force on June 1th, 2015.

See also

• Lysergamide
• Psychedelic
• LSD
• AL-LAD
• LSZ

External links

• 1P-LSD (Wikipedia)
• 1P-LSD experiences (Erowid)
• 1P-LSD (Tripsit)
• 1P-LSD (Bluelight)