DOC |
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| The skeletal formula of DOC. | |||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Chemical Nomenclature | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Common names | DOC | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Substitutive name | 2,5-Dimethoxy-4-chloroamphetamine | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Systematic name | 1-(4-chloro-2,5-dimethoxy-phenyl)propan-2-amine | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Class Membership | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Psychoactive class | Psychedelic | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Chemical class | Phenethylamine | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Routes of Administration | |||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Summary sheet: DOC |
2,5-Dimethoxy-4-chloroamphetamine (DOC) is a psychedelic drug of the substituted phenethylamine and amphetamine chemical classes.
This substance has no history of human usage prior to the 1991 publication of its synthesis and pharmacology in PiHKAL (Phenethylamines i Have Known And Loved)[1] by Alexander Shulgin. In modern times, it is used as a recreational drug and an entheogen, rarely sold on the streets and almost exclusively obtained as a grey area research chemical through the use of online vendors.
DOC is a highly dose sensitive psychedelic that is often sold on blotting paper and known for its strong visuals and intense body load. Many reports also indicate that the effects of this chemical may be overly intense for those who are not already experienced with psychedelics.
Contents
Chemistry
DOC or 4-Chloro-2,5-dimethoxy-amphetamine is a molecule of the amphetamine class. Amphetamines are substituted phenethylamines containing a phenyl ring bound to an amino (NH2) group through an ethyl chain and a methyl group bound to the alpha carbon Rα. DOC contains methoxy functional groups CH3O- attached to carbons R2 and R5 and a chlorine attached to carbon R4 of the phenyl ring. DOC is the amphetamine analogue of the phenethylamine 2C-C.[2]
Pharmacology
DOC's psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.
Subjective effects
The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.
Physical effects
- Spontaneous tactile sensations - The "body high" of DOC is manifested as somewhat intense in comparison to most classical psychedelics such as LSD. The sensation itself can be described as a constantly present yet somewhat mild energetic pins and needles sensation that encompasses a person’s entire body. It is usually felt over every square inch of the skin, but occasionally manifests itself in the form of a continuously shifting tingling sensation that travels up and down the body in spontaneous waves.
- Stimulation - In terms of its effects on the physical energy levels of the tripper, DOC is usually considered to be extremely stimulating at levels which do not become overwhelming, resulting in a shakiness and unsteadiness of the hands but encouraging one to move around, run, dance, climb and generally engage in physical activities. In comparison, other more commonly used psychedelics such as psilocin are generally sedating and relaxed.
- Tactile enhancement - Feelings of enhanced tactile sensation are consistently present at moderate levels throughout most DOC trips.
- Nausea - Mild to extreme nausea is reported when consumed in moderate to high dosages and either passes once the person has vomited or gradually fades by itself as the peak sets in.
- Vasoconstriction - This effect is usually only present at higher dosages, but can be particularly uncomfortable.
- Bodily control enhancement
- Pupil dilation
- Increased blood pressure
Cognitive effects
The cognitive effects of DOC are described by many as extreme mental stimulation combined with a powerful enhancement of a person's current mental state.
The total sum of these cognitive components regardless of the setting generally includes:
- Empathy, love and sociability enhancement - This component is consistently manifested only in the context of social settings in which one is within the company of others. These feelings of sociability, love and empathy are a little weaker and less sharp than those found on substances such as MDMA and 2C-B, but still prove strong enough to provide long-lasting therapeutic effects.
- Analysis enhancement
- Thought acceleration
- Time distortion
- Novelty enhancement
- Immersion enhancement
- Conceptual thinking
- Thought connectivity
- Emotion enhancement
- Personal bias suppression
- Memory suppression
- Ego death
- Wakefulness
- Increased libido
Visual effects
Enhancements
Distortions
- Drifting (melting, flowing, breathing and morphing) - In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion, static in appearance and unrealistic/cartoon-like in style.
- Tracers
- After images
- Symmetrical texture repetition
- Colour shifting
- Scenery slicing
- Diffraction
Geometry
The visual geometry that is present throughout this trip can be described as more similar in appearance to that of 4-AcO-DMT or ayahuasca than that of LSD, 2C-B or 2C-I. It can be comprehensively described through its variations as intricate in complexity, abstract in form, organic in feel, structured in organization, brightly lit, multicoloured in scheme, glossy in shading, sharp in edges, large in size, fast in speed, smooth in motion, equally rounded and angular in its corners, non-immersive in depth and consistent in intensity. At higher dosages this geometry is significantly more likely to result in states of level 8B visual geometry over level 8A.
Hallucinatory states
DOC and other substituted amphetamines produce a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. This holds particularly true in comparison to other substances within the phenethylamine family. These effects include:
- Transformations
- Internal hallucinations (autonomous entities; settings, sceneries, and landscapes; alterations in perspective and scenarios and plots) - In comparison to other psychedelics such as LSD, DOC is extremely high in internal hallucinations. They are more common within dark environments and can be comprehensibly described through its variations as lucid in believability, interactive in style, new experiences in content, autonomous in controllability, geometry-based in style and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.
Auditory effects
Toxicity and harm potential
 Main articles: Research chemicals § Toxicity and harm potential & Responsible use § Hallucinogens
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The toxicity and long-term health effects of recreational DOC use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because DOC is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried DOC suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
Medical literature reports multiple physical complications associated with the use of DOC. An individual's cause of death was reported as DOC toxicity and confirmed with GC-MS in the Journal of Analytical Toxicology.[3] Seizures have been associated with the use of DOC in another medical journal.[4] In 2015, an individual was hospitalized with peripheral vasoconstriction after an extreme overdose of DOC. Subsequent necrosis resulted in the amputation of several toes.[5]
It is strongly recommended that one use harm reduction practices when using this drug.
Tolerance and addiction potential
DOC is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.
Tolerance to the effects of DOC are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). DOC presents cross-tolerance with all psychedelics, meaning that after the consumption of DOC all psychedelics will have a reduced effect.
Legal issues
- Denmark: DOC is a Schedule I drug.
- Finland: The possession, production and sale is illegal.
- Israel: The possession, production and sale is illegal.
- New Zealand: DOC is a Class C drug.
- Poland: DOC is not controlled in Poland and no analog law covers it.
- Germany: DOC is listed in Anlage I in Germany, making it illegal to buy, sell, or possess without a license.
- Canada: DOC is Schedule III in Canada, making it illegal to sell, buy, or possess without a license.[6]
- U.K.: DOC is a Class A drug.
- U.S.: DOC is technically not scheduled in the United States, but could be considered an analogue of DOM or DOB and therefore a Schedule I drug.
- Latvia: DOC is a Schedule I controlled substance.[7]
See also
External links
References
- ↑ http://www.erowid.org/library/books_online/pihkal/pihkal.shtml
- ↑ http://isomerdesign.com/PiHKAL/read.php?domain=pk&id=64
- ↑ https://www.ncbi.nlm.nih.gov/pubmed/25217551/
- ↑ https://www.ncbi.nlm.nih.gov/pubmed/25553227/
- ↑ http://www.shroomery.org/forums/showflat.php/Number/21689828/fpart/1/vc/1
- ↑ http://isomerdesign.com/Cdsa/schedule.php?schedule=1§ion=18.5&structure=C
- ↑ Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem (2,5-Dimetoksifeniletānamīni) | http://likumi.lv/doc.php?id=121086
