2-Oxo-PCE
| 2-Oxo-PCE | |||||||||||||||||||||||||||
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| Common names | O-PCE, 2'-Oxo-PCE, 2O-PCE, deschloro-N-ethyl-Ketamine, eticyclidone, 3F-MeO-PCP | ||||||||||||||||||||||||||
| Systematic name | 2-(ethylamino)-2-phenylcyclohexan-1-one | ||||||||||||||||||||||||||
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| Summary sheet: 2'-Oxo-PCE |
2'-Oxo-PCE (also known as O-PCE and eticyclidone[1]) is a new dissociative NMDA receptor antagonist and anesthetic drug of the arylcyclohexylamine chemical class. It is structurally related to deschloroketamine. There has been some confusion over the identity of this compound due to strange naming by vendors; it has been sold as O-PCE, 3F-MeO-PCP, 22'-Oxo-PCE, 2'-Oxo-PCE, 22'-Oxo-PCE, deschloro-N-ethyl-Ketamine and eticyclidone.
This compound induces a state referred to as "dissociative anesthesia" when ingested and is therefore used as a recreational drug. 2'-Oxo-PCE has recently become easily accessible through online research chemical vendors[1] where it is being sold as a designer drug.
2'-Oxo-PCE is structurally very similar to deschloroketamine, which has been speculated to have antibacterial properties.[2] It is not known whether 2'-Oxo-PCE also has these properties due to the lack of sufficient scientific research. However, the possibility should be kept in mind because prolonged use could potentially pose a serious threat to one's health and immune system.
Chemistry
2'-Oxo-PCE, or 2-(ethylamino)-2-phenylcyclohexan-1-one, is classed as an arylcyclohexylamine drug. Ayrlcyclohexylamine drugs are named for their structures which include a cyclohexane ring bound to an aromatic ring along with an amine group. Deschloroketamine contains a phenyl ring bonded to a cyclohexane ring substituted with an oxo group (cyclohexanone) at R1. Bound to the adjacent alpha carbon (R2) of the cyclohexanone ring is an amino ethyl chain -NCH2CH3. 2'-Oxo-PCE, like MXE contains an amino ethyl chain rather than the amino methyl chain found in DCK and ketamine. 2'-Oxo-PCE is homologous to DCK, differing only in the length of their carbon chain.
Pharmacology
Due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is purely based on its structure and subjective effect similarities to other arylcyclohexylamine dissociatives such as DCK and ketamine. With this in mind, 2'-Oxo-PCE is thought to act as an NMDA receptor antagonist. NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually this substance's equivalent of the “K-hole.”
Subjective effects
In comparison to DCK, ketamine and MXE, this compound can be described as significantly more stimulating with fewer cognitive suppressions and more lucidity. The first half of its duration presents primarily stimulating effects with minimal dissociation whilst the second half is primarily dissociating with minimal stimulation.
The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.
Physical effects
2-Oxo-PCE causes more physical side effects than other dissociatives such as MXE, ketamine, and 3-MeO-PCP. Its side effects are comparable to diphenidine, MXP, and ephenidine.
- Stimulation - This drug is extremely stimulating when compared to other dissociatives such as ketamine, MXE, or DCK. Its stimulation can be compared to classical stimulants such as ritalin or cocaine, but less functional.
- Tactile disconnection
- Spontaneous tactile sensations
- Tactile suppression
- Physical autonomy
- Motor control loss
- Physical euphoria
- Perception of decreased weight
- Dizziness
- Nausea
- Visual sliding
- Increased heart rate - This drug can cause more physical side effects than MXE, ketamine, and 3-MeO-PCP such as increased heart rate.
Cognitive effects
- Depersonalization
- Derealization
- Consciousness disconnection
- Memory suppression
- Ego death
- Thought deceleration
- Immersion enhancement
- Information processing suppression
- Time distortion
- Euphoria
- Introspection
- Déjà vu
- Conceptual thinking
- Compulsive redosing
- Anxiety suppression
- Disinhibition
- Amnesia
- Creativity enhancement
- Mania
- Existential self-realization
Visual effects
Suppression
- Visual disconnection - This eventually results in 2'-Oxo-PCE's equivalent of the famous "k-hole" or, more specifically, holes, spaces and voids alongside of structures.
- Visual acuity suppression
- Double vision
- Pattern recognition suppression
- Frame rate suppression
Distortions
Geometry
Hallucinatory states
- Internal hallucinations (autonomous entities; settings, sceneries, and landscapes; alterations in perspective and scenarios and plots)
Auditory effects
Toxicity and harm potential
The toxicity and long-term health effects of recreational 2'-Oxo-PCE use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because 2'-Oxo-PCE has very little history of human usage. Anecdotal evidence from people who have tried 2'-Oxo-PCE within the community suggest that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed).
2'-Oxo-PCE is structurally very similar to deschloroketamine, which has been speculated to have immuno-modulative properties.[2] It is not known whether 2'-Oxo-PCE also has these properties due to the lack of sufficient scientific research. However, the possibility should be kept in mind because prolonged use could potentially pose a serious threat to one's health and immune system.
It is strongly recommended that one use harm reduction practices when using this drug.
Tolerance and addiction potential
As with other NMDA receptor antagonists, the chronic use of 2'-Oxo-PCE can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage.
Tolerance to many of the effects of 2'-Oxo-PCE develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). 2'-Oxo-PCE presents cross-tolerance with all dissociatives, meaning that after the consumption of 2'-Oxo-PCE all dissociatives will have a reduced effect.
Urinary tract effects
In terms of its long-term health effects when used repeatedly and with excess for extended periods of time, 2'-Oxo-PCE seems to exhibit almost identical bladder and urinary tract problems to those found within ketamine but to a lesser extent. This is because 2'-Oxo-PCE is a little more potent than ketamine, meaning that less of the drug needs to be consumed. Symptoms of ketamine-induced cystitis can become extremely serious and can be described as:
- Urinary frequency - Urinary frequency is the need to empty the bladder every few minutes.
- Urinary urgency - This can be described as a sudden, compelling need to urinate.
- Urinary pressure - This is experienced as a constant sensation of fullness in the bladder that is unrelieved by urination.
- Pelvic and bladder pain - Pain can develop suddenly and severely, particularly as the bladder fills with urine.
- Hematuria - Hematuria is visible blood in the urine.
- Incontinence - This is the leakage of urine.
All of these, however, can easily be avoided by simply not using 2'-Oxo-PCE on a daily or even weekly basis and manually limiting one's usage of the substance.
Dangerous interactions
Although many drugs are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
- Depressants - This combination potentiates the muscle relaxation, sedation and amnesia caused by one another and can lead to unexpected loss of consciousness at high doses. There is also an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If this occurs, users should attempt to fall asleep in the recovery position or have a friend move them into it. Examples include 1,4-butanediol, 2-methyl-2-butanol, benzodiazepines, GHB, GBL, and opioids.
Legal issues
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This legality section is a stub. As such, it likely contains incomplete or wrong information. You can help by expanding it. |
- United Kingdom - It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.[3]
See also
External links
References
- ↑ 1.0 1.1 The Big & Dandy 2'-Oxo-PCE / 2'-Oxo-PCE Thread | http://www.bluelight.org/vb/threads/767905-The-Big-amp-Dandy-2'-Oxo-PCE-2-Oxo-PCE-Thread
- ↑ 2.0 2.1 Patent US 3254124 - Aminoketones and methods for their production | http://www.google.com/patents/US3254124
- ↑ Psychoactive Substances Act 2016 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/2016/2/contents/enacted