Methoxphenidine

Methoxphenidine
The skeletal formula of methoxphenidine
Chemical Nomenclature
Common names	Methoxphenidine, MXP
Substitutive name	2-MeO-Diphenidine
Systematic name	(±)-1-[1-(2-methoxyphenyl)-2-phenylethyl]piperidine
Class Membership
Psychoactive class	Dissociative
Chemical class	Piperidine
Routes of Administration
Oral Dosage WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation. This dosage and duration information has been sourced from TripSit Threshold 30 - 50 mg Light 50 - 75 mg Common 75 - 120 mg Strong 120 - 150 mg Duration Total 6 - 8 hours Onset 30 - 60 minutes After effects 1 - 3 hours

Summary sheet: Methoxphenidine

Methoxphenidine (MXP) or 1-[1-(2-methoxyphenyl)-2-phenylethyl]piperidine is a hallucinogenic dissociative compound of the diarylethylamine chemical class that has been sold online as a designer drug. It induces a state referred to as "dissociative anesthesia" and has similar effects to that of the arylcyclohexylamine and morphinan classes of dissociatives.

This compound was first reported in a 1989 patent where it was tested as a treatment for neurotoxic injury. Shortly after the 2013 UK ban on arylcyclohexylamines methoxphenidine and the related compound diphenidine became available on the gray market, where it has been encountered as a powder and in tablet form. It is often marketed as a replacement for MXE despite many users reporting it as qualitatively different in its effects.

Chemistry

General formula of a piperdine molecule.

Methoxphenidine, or 2-MeO-Diphenidine is a molecule of the diarylethylamine class. It contains a substituted phenethylamine skeleton with an additional phenyl ring bound to R_α. The terminal amino group of the phenethylamine chain is incorporated into a piperidine ring. Hence, methoxphenidine belongs to the piperidine dissociative class of compounds. Methoxphenidine is structurally analogous to Diphenidine, containing an additional 2-methoxy CH₃O- substitution.

Pharmacology

Main article: NMDA receptor antagonist

MXP acts as an NMDA receptor antagonist. NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually an almost identical equivalent of the famous “k-hole.”

Although it has not been formally studied, the feelings of physical and emotional euphoria which many users report suggests that it may also have action as a dopamine and / or a noradrenaline reuptake inhibitor.

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical effects

The subjective physical effects of MXP are most similar to that of DXM than any other commonly used dissociative. They can be broken down into several components which progressively intensify proportional to dosage. These are described below and generally include:

• Tactile disconnection - This results in typical states of progressive physical disconnection but is far more consciously controllable than that of other dissociatives. This allows one to choose how much of their body they are currently aware of and connected to simply by directing their focus towards it even throughout higher states of disconnection and out-of-body experiences.
• Spontaneous tactile sensations - The MXP "body high" is a soft, pleasurable vibrating sensation which can be felt all over the body which progressively intensifies throughout the onset before dissipating once the peak has been reached.
• Tactile suppression - This partially to entirely suppresses one's own sense of touch, creating feelings of numbness within the extremities. It is responsible for the anaesthetic properties of this substance.
• Motor control loss - A loss of gross and fine motor control alongside of balance and coordination is prevalent within MXP and becomes especially strong at higher dosages. This means that one should be sitting down before the onset unless they are experienced in case of falling over and injuring oneself.
• Euphoria - This results in feelings of physical euphoria which range between mild pleasure to powerfully all-encompassing bliss.
• Perception of decreased weight - This creates the sensation that the body is floating and has become entirely weightless. This effect is strangely stimulating and encourages physical activities at low to moderate dosages by making the body feel light and effortless to move.
• Dizziness - Although uncommon, some people report dizziness under the influence of MXP.
• Physical autonomy

Cognitive effects

The cognitive effects of MXP are often described as particularly clear-headed in comparison to other dissociatives even at heavy dosages. It is far more controllable, less disorientating and confusing at dosages of equal subjective intensity to that of MXE, DXM and ketamine. The cognitive effects of MXP can be broken down into several separate subcomponents which are listed and described below:

• Depersonalization
• Derealization
• Consciousness disconnection
• Thought acceleration
• Memory suppression
• Ego death
• Thought deceleration
• Information processing suppression
• Time distortion - Feelings of time dilation and more time having passed than it actually has are common at moderate to strong dosages.
• Euphoria
• Conceptual thinking
• Anxiety suppression
• Disinhibition
• Amnesia

Visual effects

Suppression

• Visual disconnection - This eventually results in MXP's equivalent of the famous "K-hole" or more specifically, holes, spaces and voids alongside of structures.
• Visual acuity suppression
• Double vision - This component is prevalent at moderate to heavy dosages and makes reading impossible unless one closes an eye.
• Pattern recognition suppression - This effect generally occurs at higher dosages and makes one unable to recognize and interpret perceivable visual data.
• Frame rate suppression

Distortions

• Perspective distortions
• Environmental cubism
• Environmental orbism
• Scenery slicing

Hallucinatory states

At high dosages, MXP can produce a full range of high level hallucinatory states in a fashion that is less consistent and reproducible than that of many other commonly used psychedelics. These effects include:

• Internal hallucinations (autonomous entities; settings, sceneries, and landscapes; alterations in perspective and scenarios and plots) - In comparison to other dissociatives, this effect can occur at heavy dosages, but is considerably less common than the same effect found within psychedelics and deliriants. It feels very dream-like and can be comprehensively described through its variations as delirious in believability, fixed in style, equal in new experiences and memory replays in content, extremely controllable in content and solid in style.

Auditory effects

• Suppression
• Distortions
• Hallucinations

Afterglow

The afterglow is a feeling that occurs within the 24 hours after the trip itself. It is long-lasting and as equally enjoyable as the trip itself to many people. It can be be described in terms of its physical sensation as one of euphoria, rejuvenation, relaxation and a light bounciness. In terms of its mental thought processes however, it can be described as a complete loss of anxiety, feelings of contentedness and an extremely high appreciation for music which dissipates a day or so after the experience.

Toxicity and harm potential

Main article: Research chemicals § Toxicity and harm potential

The toxicity and long-term health effects of recreational MXP use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because MXP has very little history of human usage. Anecdotal evidence from people who have tried MXP within the community suggest that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

As with other NMDA receptor antagonists, the chronic use of MXP can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage.

Tolerance to many of the effects of MXP develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). MXP presents cross-tolerance with all dissociatives, meaning that after the consumption of MXP all dissociatives will have a reduced effect.

Dangerous interactions

Although many drugs are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

• Depressants - This combination potentiates the muscle relaxation, sedation and amnesia caused by one another and can lead to unexpected loss of consciousness at high doses. There is also an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If this occurs, users should attempt to fall asleep in the recovery position or have a friend move them into it. Examples include 1,4-butanediol, 2-methyl-2-butanol, benzodiazepines, GHB, GBL, and opioids.

Legal issues

This legality section is a stub. As such, it likely contains incomplete or wrong information. You can help by expanding it.

• United Kingdom - It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.
• China - As of October 2015 MXP is a controlled substance in China.
• Sweden - MXP is also banned in Sweden.

Experience reports

Anecdotal reports which describe this compound within our experience index include:

Additional experience reports can be found here:

• Erowid Experience Vaults: MXP

See also

• Responsible use
• Diphenidine
• Dissociative
• MXE
• DXM

External links

• MXP (Wikipedia)
• MXP (Erowid)
• MXP (TripSit)
• MXP (Bluelight)
• MXP experiences (Erowid)