3-MeO-PCP

3-MeO-PCP may cause psychosis and mania at a significantly higher rate than other dissociatives.

It is strongly discouraged to abuse this substance multiple days in a row or in high doses. Please see this section for more details.

3-MeO-PCP
Chemical Nomenclature
Common names	3-MeO-PCP
Substitutive name	3-Methoxyphencyclidine
Systematic name	1-[1-(3-methoxyphenyl)cyclohexyl]-piperidine
Class Membership
Psychoactive class	Dissociative
Chemical class	Arylcyclohexylamine
Routes of Administration
Oral Dosage WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy. Threshold 1.5 - 3 mg Light 3 - 5 mg Common 5 - 10 mg Strong 10 - 15 mg Heavy 15+ mg Heavy doses may result in psychosis and mania. Duration Total 3 - 5 hours Onset 20 - 40 minutes After effects 2 - 48 hours Insufflated Dosage WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy. Threshold 1 - 2 mg Light 2 - 5 mg Common 5 - 8 mg Strong 8 - 12 mg Heavy 12mg+ Heavy doses may result in psychosis and mania. Duration Total 2 - 4 hours Onset 10 - 30 minutes After effects 2 - 48 hours

Summary sheet: 3-MeO-PCP

3-MeO-PCP (3-Methoxyphencyclidine) is a chemical of the arylcyclohexylamine class which acts as a hallucinogenic dissociative.

The compound was first synthesized in 1979 to investigate the structure-activity relationship of phencyclidine derivatives. The activity of 3-MeO-PCP in humans was not described until 1999 when a chemist using the pseudonym John Q. Beagle wrote that 3-MeO-PCP was qualitatively similar to PCP with comparable potency. Today it is used as a recreational drug and an entheogen, rarely sold on the streets and almost exclusively obtained as a grey area research chemical through the use of online vendors.

Chemistry

3-MeO-PCP, or 3-Methoxyphencyclidine, is a synthetic dissociative of the arylcyclohexylamine class. 3-MeO-PCP contains cyclohexane, a six member saturated ring, bonded to two additional rings at R₁. One of these rings is a piperidine ring, a nitrogenous six member ring, bonded at its nitrogen group. The other ring is an aromatic phenyl ring, substituted at R₃ with a methoxy group.

3-MeO-PCP is a PCP derivative and structurally analogous to 4-MeO-PCP.

Pharmacology

Main article: NMDA receptor antagonist

3-MeO-PCP acts as an NMDA receptor antagonist. NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually an almost identical equivalent of the famous “k-hole.”

3-MeO-PCP has a Ki of 20 nM for the NMDA receptor, 216 nM for the serotonin transporter and 42 for the sigma1 receptor. It binds to the NMDA receptor with higher affinity than PCP and has the highest affinity of the three isomeric anisyl-substitutions, followed by 2-MeO-PCP and 4-MeO-PCP.

Although 3-MeO-PCP is often described as having opioid or dopaminergic activity, this supposition is contradicted by data showing 3-MeO-PCP to be a potent and selective ligand for the NMDA receptor without appreciable affinity for the µ-opioid receptor or dopamine transporter. 3-MeO-PCP was preceded by the less potent dissociative 4-MeO-PCP and first became available as a research chemical in 2011.

Subjective effects

3-MeO-PCP can be said to feel considerably more stimulating and less sedating than other dissociatives such as ketamine or MXE. At lower doses, it presents sensory enhancements such as colour enhancement, acuity enhancement, tactile enhancement, auditory enhancement and bodily control enhancement. However, at higher doses, it presents sensory suppressions such as tactile suppression, motor control loss, auditory suppression and acuity suppression. It is also considerably more likely to induce psychosis than other dissociatives and is therefore potentially dangerous regardless of setting.

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical effects

• Increased heart rate
• Tactile disconnection
• Spontaneous tactile sensations
• Tactile enhancement and Tactile suppression
• Bodily control enhancement and Motor control loss
• Stimulation - This drug is extremely stimulating in comparison to other dissociatives such as ketamine, MXE, or DCK.
• Physical autonomy
• Physical euphoria
• Perception of decreased weight
• Dizziness
• Nausea

Cognitive effects

• Psychosis - This effect is more common on 3-MeO-PCP than other dissociatives (such as ketamine or MXE). It commonly occurs during the offset of the trip.
• Mania - This effect is more common on 3-MeO-PCP than other dissociatives. It commonly occurs during the offset of the trip.
• Mindfulness
• Depersonalization
• Derealization
• Consciousness disconnection
• Memory suppression
• Ego death
• Thought deceleration
• Immersion enhancement
• Information processing suppression
• Time distortion
• Euphoria
• Introspection
• Déjà vu
• Conceptual thinking
• Compulsive redosing
• Anxiety suppression
• Disinhibition
• Amnesia
• Feelings of impending doom
• Creativity enhancement
• Existential self-realization

Enhancements

• Colour enhancement
• Acuity enhancement

Suppressions

• Visual disconnection - This eventually results in 3-MeO-PCP's equivalent of the famous "k-hole" or more specifically, holes, spaces and voids alongside of structures.
• Visual acuity suppression
• Double vision
• Pattern recognition suppression
• Frame rate suppression

Distortions

• Perspective distortions
• Environmental cubism
• Environmental orbism
• Scenery slicing

Hallucinatory states

• Internal hallucinations (autonomous entities; settings, sceneries, and landscapes; alterations in perspective and scenarios and plots)

Auditory effects

• Suppression and enhancement
• Distortions
• Hallucinations

Toxicity and harm potential

Main article: Research chemicals § Toxicity and harm potential

The toxicity and long-term health effects of recreational 3-MeO-PCP use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because 3-MeO-PCP has very little history of human usage.

Psychosis

3-MeO-PCP has been reported to cause psychosis and mania at a significantly higher rate than other dissociatives such as ketamine, diphenidine, or MXE. There are a large number of experience reports online which describe states of "psychotic delirium, amnesia, mania, and other serious consequences" after abusing the drug. In some cases, it has resulted in hospitalization and occasionally has taken up to a week or more to resolve.

It is strongly recommended that one use extreme caution and harm reduction practices when using this drug.

• Users should avoid taking the drug multiple days in a row or becoming addicted to it as this increases the risk of severe adverse effects.
• The recommended dosage range should not be exceeded as high doses can trigger these effects as well.
• Users should start with extremely low doses and work their way up as slowly as possible. Volumetric liquid dosing should preferably be used due to the drug's potency; most standard milligram scales cannot accurately weigh out doses below 10-15mg.
• Compulsive redosing before one has fully sobered up is not recommended and can result in too high of a dose.

Due to the risk of psychosis, it is not recommended to combine this drug with other substances, especially stimulants, psychedelics, or other dissociatives like MXE. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

The chronic use of 3-MeO-PCP can be considered highly addictive with a high potential for adverse side effects such as psychosis. In comparison to other dissociatives, 3-MeO-PCP has been reported to be more addictive than MXE, diphenidine, ephenidine, and ketamine. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage. There have been multiple reports across the internet of people becoming seriously addicted daily users of this substance so serious precautions and considerations should be taken before trying this substance.

Tolerance to many of the effects of 3-MeO-PCP develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). 3-MeO-PCP presents cross-tolerance with all dissociatives, meaning that after the consumption of 3-MeO-PCP, all dissociatives will have a reduced effect.

Urinary tract effects

In terms of its long-term health effects when used repeatedly and with excess for extended periods of time, 3-MeO-PCP seems to exhibit almost identical bladder and urinary tract problems to those found within ketamine, but to a lesser extent. This is because 3-MeO-PCP is far more potent than ketamine so significantly less of drug needs to be consumed. Symptoms of ketamine-induced cystitis can become extremely serious and can be described as:

• Urinary frequency - Urinary frequency is the need to empty the bladder every few minutes.
• Urinary urgency - This can be described as a sudden, compelling need to urinate.
• Urinary pressure - This is experienced as a constant sensation of fullness in the bladder that is unrelieved by urination.
• Pelvic and bladder pain - Pain can develop suddenly and severely, particularly as the bladder fills with urine.
• Hematuria - Hematuria is visible blood in the urine.
• Incontinence - This is the leakage of urine.

All of these, however, can easily be avoided by simply not using 3-MeO-PCP on a daily or even weekly basis and manually limiting one's usage of the substance.

Dangerous interactions

Although many drugs are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

• Psychedelics - This combination is not advised because 3-MeO-PCP has been reported to cause extreme psychological disturbances such as psychosis and mania at a significantly higher rate than other dissociatives.
• Stimulants - This combination is not advised because 3-MeO-PCP has been reported to cause extreme psychological disturbances such as psychosis and mania at a significantly higher rate than other dissociatives.
• Depressants - This combination potentiates the muscle relaxation, sedation and amnesia caused by one another and can lead to unexpected loss of consciousness at high doses. There is also an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If this occurs, users should attempt to fall asleep in the recovery position or have a friend move them into it. Examples include 1,4-butanediol, 2-methyl-2-butanol, benzodiazepines, GHB, GBL, and opioids.

Legal issues

This legality section is a stub. As such, it likely contains incomplete or wrong information. You can help by expanding it.

• United Kingdom - It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.
• Sweden - Sweden's public health agency suggested classifying 3-MeO-PCP as a hazardous substance on November 10, 2014.
• Germany - On November 21, 2015, 3-MeO-PCP was added to "Anlage II" of the controlled substance act ("BtMG"), making it illegal to produce, sell or possess.

Experience reports

Anecdotal reports which describe this compound within our experience index include:

• Experience:3-MeO-PCP (repeated) - York Bowen
• Experience:3-MeO-PCP, LSD,Clonazolam, Amphetamine- Excessive Amounts and Excessive Confusion

Additional experience reports can be found here:

• Erowid Experience Vaults: 3-MeO-PCP

See also

• Responsible use
• 4-MeO-PCP
• PCP
• Dissociatives
• Arylcyclohexylamines

External links

• 3-MeO-PCP (Wikipedia)
• 3-MeO-PCP experiences (Erowid)
• 3-MeO-PCP (Bluelight)
• 3-MeO-PCP (Tripsit)