Diphenidine

Diphenidine
The skeletal formula of diphenidine
Chemical Nomenclature
Common names	Diphenidine
Systematic name	(±)-1-(1,2-Diphenylethyl)piperidine
Class Membership
Psychoactive class	Dissociative
Chemical class	Piperidine
Routes of Administration
Oral Dosage WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy. Threshold 50 mg Light 70 - 85 mg Common 85 - 110 mg Strong 110 - 150 mg Heavy > 150 mg Duration Total 2 - 5 hours Onset 15 - 30 minutes After effects 4 - 24 hours

Summary sheet: Diphenidine

Diphenidine (1-(1,2-diphenylethyl)piperidine) is a dissociative NMDA receptor antagonist and anesthetic of the piperidine class that has been sold online as a research chemical.

The synthesis of diphenidine was first reported in 1924 and employed a nitrile displacement reaction analogous to the one that would later be used to discover phencyclidine in 1956. Shortly after the 2013 UK ban on arylcyclohexylamines, diphenidine and the related compound methoxphenidine became available on the grey market. Anecdotal reports describe high doses of diphenidine producing "bizarre somatosensory phenomena and transient anterograde amnesia."

In 2014, there have been two published reports of diphenidine being sold in combination with synthetic cannabinoids in Japanese herbal incense blends. A herbal incense sold in the Shizuoka Prefecture under the name "Aladdin (sic) Spacial Edition" was found to contain diphenidine and 5-fluoro-AB-PINACA at concentrations of 289 mg/g and 55.5 mg/g, respectively. Another product called ‘‘Herbal Incense. The Super Lemon’’ containing AB-CHMINACA, 5F-AMB, and diphenidine was implicated in a fatal overdose.

Based on collaborative anecdotal evidence, diphenidine seems to have a much more rapid onset and lower half-life when vaporized or smoked. When consumed this way, it is a suspected to be carcinogenic when excess heat is used. Some user reports have concluded that vaporization requires as low as 20% of what would be a common oral dose for that person.

Chemistry

General formula of a piperdine molecule.

Diphenidine is a molecule of the diarylethylamine class. It contains a substituted phenethylamine skeleton with an additional phenyl ring bound to R_α. The terminal amino group of the phenethylamine chain is incorporated into a piperidine ring. Hence, diphenidine belongs to the piperidine dissociative class of compounds. Diphenidine is structurally analogous to MXP, lacking a 2-methoxy substitution on one of its phenyl rings.

Pharmacology

Main article: NMDA receptor antagonist

Diphenidine acts as an NMDA receptor antagonist. NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually the famous “hole”.

Although vendors of diphenidine have stated the compound acts as a dopamine-reuptake inhibitor and a serotonin reuptake inhibitor with µ-opioid affinity and typical dissociative effects, to date diphenidine has not been screened for affinity at the dopamine transporter. If this is indeed the case, however, it provides an explanation for its euphoric and often stimulating effects.

Diphenidine and related diarylethylamines have been studied in vitro as treatments for neurotoxic injury. Diphenidine may be a stronger NMDA receptor antagonist for neurogenesis, neurological repair and neuroprotection than other more common NMDA receptor antagonistic dissociatives such as ketamine, dextromethorphan, PCP analogs, Iboga and methoxetamine.

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical effects

• Tactile disconnection
• Spontaneous tactile sensations - The diphenidine "body high" is a sharp, pleasurable tingling sensation which is location specific to the hands, feet and head.
• Tactile suppression - This partially to entirely suppresses one's own sense of touch, creating feelings of numbness within the extremities. It is responsible for the anaesthetic properties of this substance.
• Physical autonomy
• Stimulation
• Increased heart rate
• Motor control loss - A loss of gross and fine motor control alongside of balance and coordination is prevalent within diphenidine and becomes especially strong at higher dosages. This means that one should be sitting down before the onset (unless one is experienced) in case of falling over and injuring oneself.
• Euphoria - This results in feelings of physical euphoria which range between mild pleasure to moderate all-encompassing bliss.
• Perception of decreased weight - This creates the sensation that the body is floating and has become entirely weightless. This effect is strangely stimulating and encourages physical activities at low to moderate dosages by making the body feel light and effortless to move.
• Dizziness - Although uncommon, some people report dizziness under the influence of diphenidine.
• Nausea - It's worth noting that high dose diphenidine trips can sometimes result in nausea and vomiting at the peak of the trip. For most people, this is surprisingly not as unpleasant as they would initially expect due to the accompanying detachment from the physical senses.

Cognitive effects

The general head space of diphenidine is often described as particularly euphoric and clear-headed in comparison to that of DXM and ketamine. The specific cognitive effects can be broken down into several separate subcomponents which are listed and described below:

• Depersonalization
• Derealization
• Consciousness disconnection
• Memory suppression
• Ego death
• Thought deceleration
• Information processing suppression
• Time distortion
• Euphoria
• Introspection
• Déjà vu
• Conceptual thinking
• Compulsive redosing
• Anxiety suppression
• Disinhibition
• Amnesia

Visual effects

Suppression

• Visual disconnection - This eventually results in the diphenidine's equivalent of the famous "K-hole" or more specifically, holes, spaces and voids alongside of structures.
• Visual acuity suppression
• Double vision - This component is prevalent at moderate to heavy dosages and makes reading impossible unless one closes an eye.
• Pattern recognition suppression - This effect generally occurs at higher dosages and makes one unable to recognize and interpret perceivable visual data.
• Frame rate suppression

Distortions

• Perspective distortions
• Environmental cubism
• Environmental orbism
• Scenery slicing

Geometry

The visual geometry found within diphenidine can be described as very dark and bland when compared to that of ketamine or DXM and often consists of many tiny interlocking and woven lines. It does not extend beyond level 4 and can be comprehensively described through its variations as simplistic in complexity, algorithmic in style, synthetic in feel, unstructured in organization, dimly lit in lighting, multicoloured in scheme, glossy in shading, soft in edges, small in size, slow in speed, smooth in motion, equal in rounded and angular corners, immersive in depth and consistent in intensity.

Hallucinatory states

At high dosages, diphenidine can produce a full range of high level hallucinatory states in a fashion that is less consistent and reproducible than that of many other commonly used psychedelics. These effects include:

• Internal hallucinations (autonomous entities; settings, sceneries, and landscapes; alterations in perspective and scenarios and plots) - In comparison to other dissociatives, this effect can occur at heavy dosages, but is considerably less common than the same effect found within psychedelics and deliriants. It can be comprehensively described through its variations as delirious in believability, fixed in style, equal in new experiences and memory replays in content, autonomous in controllability and solid in style.

Auditory effects

• Enhancements
• Suppression
• Distortions
• Hallucinations

Toxicity and harm potential

Main article: Research chemicals § Toxicity and harm potential

The toxicity and long-term health effects of recreational diphenidine use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because diphenidine has very little history of human usage. Anecdotal evidence from people who have tried diphenidine within the community suggest that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

As with other NMDA receptor antagonists, the chronic use of diphenidine can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage.

Tolerance to many of the effects of diphenidine develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). Diphenidine presents cross-tolerance with all dissociatives, meaning that after the consumption of diphenidine all dissociatives will have a reduced effect.

Dangerous interactions

Although many drugs are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

• Depressants - This combination potentiates the muscle relaxation, sedation and amnesia caused by one another and can lead to unexpected loss of consciousness at high doses. There is also an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If this occurs, users should attempt to fall asleep in the recovery position or have a friend move them into it. Examples include 1,4-butanediol, 2-methyl-2-butanol, benzodiazepines, GHB, GBL, and opioids.

Legal issues

Diphenidine is currently a legal grey area drug worldwide and is easily accessible through the use of online research chemical vendors. However, this does not guarantee anyone to be immune from legal prosecution should they be found in possession of this substance as the legality is likely to vary from country to country.

• United Kingdom - It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.

Experience reports

Anecdotal reports which describe this compound within our experience index include:

• Experience:300mg 1P-LSD + 40mg diphenidine - My first psychotic break
• Experience:50mg - Diphenidine ride

See also

• Responsible use
• Dissociative
• Methoxphenidine
• Ephenidine
• Methoxetamine

External links

• Diphenidine (Wikipedia)
• Diphenidine (Erowid)
• Diphenidine (Bluelight)
• Diphenidine (TripSit)
• Diphenidine experiences (Erowid)