Deschloroketamine

Summary sheet: Deschloroketamine

Deschloroketamine
Chemical Nomenclature
Common names	Deschloroketamine, DXE, DCK, 2'-Oxo-PCM
Systematic name	2-Phenyl-2-(methylamino)cyclohexanone
Routes of Administration
Insufflated Dosage WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy. Threshold 2 - 5 mg Light 5 - 15 mg Common 15 - 25 mg Strong 25 - 50 mg Heavy 50 mg + Duration Total 2 - 6 hours Onset 10 - 30 minutes Peak 60 - 90 minutes

Deschloroketamine (also called DXE, DCK, or 2'-Oxo-PCM) is a chemical of the arylcyclohexylamine class which acts as a hallucinogenic dissociative anesthetic.

This compound induces a state referred to as "dissociative anesthesia" when ingested and is therefore used as a recreational drug. DCK has recently become easily accessible through online research chemical vendors where it is being sold as a designer drug.

As DCK has been speculated to have antibacterial properties, its prolonged use could potentially pose a serious threat to one's health and immune system.

Chemistry

Deschloroketamine, or 2-Phenyl-2-(methylamino)cyclohexanone, is classed as an arylcyclohexylamine drug. Ayrlcyclohexylamine drugs are named for their structures which include a cyclohexane ring bound to an aromatic ring along with an amine group. Descholoroketamine contains a phenyl ring bonded to a cyclohexane ring substituted with an oxo group (cyclohexanone). An amino methyl chain (-N-CH₃) is bound to the adjacent alpha carbon (R₂) of the cyclohexanone ring.

Descholoroketamine is a chiral molecule and is often produced as a racemate. Des- is a prefix used in chemistry to denote the absence of a functional group (in this case "chloro") hence deschloroketamine is named for lacking a chlorine substitution on its phenyl ring, which is found in ketamine.

Pharmacology

Main article: NMDA receptor antagonist

Due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is purely based on its structure and subjective effect similarities to other arylcyclohexylamine dissociatives such as 3-MeO-PCP, PCP and MXE. With this in mind, DCK is thought to act as an NMDA receptor antagonist. NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually this substance's equivalent of the “K-hole.”

Subjective effects

In terms of its subjective effects, this compound feels closer to that of ketamine and MXE than more stimulating compounds of the same class such as 3-MeO-PCP, 2'-Oxo-PCE and PCP. It is therefore a more suitable ketamine substitute than many other popular arylcyclohexylamines. As of 2016, this compound is currently the best substitute for MXE that is widely available for purchase as it has a similar dosage range and similar subjective effects.

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical effects

• Muscle relaxation
• Tactile disconnection
• Spontaneous tactile sensations
• Tactile suppression
• Physical autonomy
• Motor control loss
• Physical euphoria
• Perception of decreased weight
• Dizziness
• Nausea
• Visual sliding
• Decreased libido

Cognitive effects

• Depersonalization
• Derealization
• Consciousness disconnection
• Memory suppression
• Ego death
• Thought deceleration
• Immersion enhancement
• Information processing suppression
• Time distortion
• Euphoria
• Introspection
• Déjà vu
• Conceptual thinking
• Compulsive redosing
• Anxiety
• Disinhibition
• Amnesia
• Creativity enhancement
• Language suppression
• Existential self-realization

Visual effects

Suppression

• Visual disconnection - This eventually results in DCK's equivalent of the famous "k-hole" or, more specifically, holes, spaces and voids alongside of structures.
• Visual acuity suppression
• Double vision
• Pattern recognition suppression
• Frame rate suppression

Distortions

• Perspective distortions
• Environmental cubism
• Environmental orbism
• Scenery slicing

Hallucinatory states

• Internal hallucinations (autonomous entities; settings, sceneries, and landscapes; alterations in perspective and scenarios and plots)

Auditory effects

• Suppression
• Distortions
• Hallucinations

Toxicity and harm potential

Main article: Research chemicals § Toxicity and harm potential

The toxicity and long-term health effects of recreational DXE use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because DCK has very little history of human usage. Anecdotal evidence from people who have tried DCK within the community suggest that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

As DCK has been speculated to have antibacterial properties, its prolonged use could potentially pose a serious threat to one's health and immune system.

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

As with other NMDA receptor antagonists, the chronic use of DCK can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage.

Tolerance to many of the effects of DCK develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). DCK presents cross-tolerance with all dissociatives, meaning that after the consumption of DXE all dissociatives will have a reduced effect.

Urinary tract effects

In terms of its long-term health effects when used repeatedly and with excess for extended periods of time, DCK seems to exhibit almost identical bladder and urinary tract problems to those found within ketamine but to a lesser extent. This is because DCK is a little more potent than ketamine, meaning that less of the drug needs to be consumed. Symptoms of ketamine-induced cystitis can become extremely serious and can be described as:

• Urinary frequency - Urinary frequency is the need to empty the bladder every few minutes.
• Urinary urgency - This can be described as a sudden, compelling need to urinate.
• Urinary pressure - This is experienced as a constant sensation of fullness in the bladder that is unrelieved by urination.
• Pelvic and bladder pain - Pain can develop suddenly and severely, particularly as the bladder fills with urine.
• Hematuria - Hematuria is visible blood in the urine.
• Incontinence - This is the leakage of urine.

All of these, however, can easily be avoided by simply not using DCK on a daily or even weekly basis and manually limiting one's usage of the substance.

Dangerous interactions

Although many drugs are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

• Depressants - This combination potentiates the muscle relaxation, sedation and amnesia caused by one another and can lead to unexpected loss of consciousness at high doses. There is also an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If this occurs, users should attempt to fall asleep in the recovery position or have a friend move them into it. Examples include 1,4-butanediol, 2-methyl-2-butanol, benzodiazepines, GHB, GBL, and opioids.

Legal issues

This legality section is a stub. As such, it likely contains incomplete or wrong information. You can help by expanding it.

• Latvia - Deschloroketamine is illegal in Latvia.
• United Kingdom - It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.

See also

• Responsible use
• Dissociative
• 2'-Oxo-PCE
• Ketamine
• 3-MeO-PCP

External links

• Deschloroketamine (Wikipedia)
• Deschloroketamine (Bluelight)
• Deschloroketamine (Reddit)
• Deschloroketamine experiences (Erowid)