LSA
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LSA
The skeletal formula of LSA
LSA.png
LSA3D.gif
Chemical Nomenclature
Common names LSA
Substitutive name d-lysergic acid amide, Ergine, d-lysergamide
Systematic name (8β)-9,10-didehydro-6-methyl-ergoline-8-carboxamide
Class Membership
Psychoactive class Psychedelic
Chemical class Lysergamide
Routes of Administration



Oral
Dosage
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.
DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Dosage differs between Morning glory seeds & Hawaiian Baby Woodrose seeds
Duration
Total 5 - 10 hours
Onset 20 minutes - 2 hours
Peak 2 - 7 hours
Offset 1 - 2 hours
After effects 0 - 3 hours +









Summary sheet: LSA

LSA (also known as ergine, d-lysergic acid amide and d-lysergamide) is a naturally occurring hallucinogenic psychedelic alkaloid of the lysergamide family. It is thought to be the active compound within many plants such as morning glory seeds, Hawaiian baby woodrose seeds and some species of fungi.

LSA was assayed for human activity by Albert Hofmann in self-trials in 1947 (well before it was known to be a natural compound). Intramuscular administration of a 500 microgram dose led to a tired, dreamy state with an inability to maintain clear thoughts. After a short period of sleep, the effects were gone and normal baseline was recovered within five hours.[1]

This suggests that the notion of LSA as the main psychedelic compound within morning glory seeds and Hawaiian baby woodrose is debatable as these reports suggest that the effects of synthetic LSA are only slightly psychedelic. Therefore it is reasonable to assume that the experience may perhaps instead be triggered by a mixture of various lysergamides within these plant materials instead of one specific compound.

Chemistry

LSA, or d-lysergic acid amide, is a semi-synthethic alkaloid of the lysergamide famiy. It contains a core structure of lysergic acid with an amine functional group bound to RN of the chemical structure. This core polycyclic structure is an indole derivative, and has tryptamine and phenethylamine groups embedded within it.

The structure contains a bicyclic hexahydroindole fused to a bicyclic quinoline group (lysergic acid). At carbon 8 of the quinoline, an acetamide group is bound. LSA is additionally substituted at carbon 6 with a methyl group. It is a chiral compound with two stereocenters at R5 and R8. LSA, also called (+)-D-LSA, has an absolute configuration of (5R, 8R). The three other stereoisomers of LSA do not have psychoactive properties. LSA is structurally analogous to LSD; LSA lacks the diethyl substitution of LSD at RN of its carboxamide group.

Pharmacology

Main article: Serotonergic psychedelic

LSA's psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical effects

  • Spontaneous tactile sensations - The "body high" of LSA can be described as a mild yet pleasurable and soft tingling sensation. This is largely noticed in high doses and is accompanied by strong waves of physical euphoria which are usually manifested spontaneously at different unpredictable points throughout the trip but can also maintain a consistent presence. In either case,LSA tends to be sedating; however,climbing or dancing,it can be setting dependent. For example,it is consistently relaxing,it is fully capable of becoming stimulating and energetic. In contrast,peaceful and sedating.
  • Vasoconstriction - LSA has strong and pronounced feelings of vasoconstriction. This varies in its intensity between individuals but is often considered uncomfortable in comparison to other psychedelics.
  • Motor control loss - This effect becomes far more present at high doses than lower doses. It can be compared to the loss of motor control experienced with alcohol-induced inebriation and is strengthened by the perception of increased weight.
  • Perception of increased weight
  • Pupil dilation - They steadily rise with the onset and hit their limit once the peak has been reached.
  • Physical euphoria
  • Sedation - In terms of its effects on the physical energy levels of the tripper,when taken in calm environments such as darkened rooms with comfortable seating,when taken in settings with large amounts of stimuli or during physically strenuous activities such as walking.

Cognitive effects

The cognitive effects of LSA are described by many as extremely relaxing yet lucid and clear-headed in style when compared to other commonly used psychedelics such as LSD or psilocin. Although it is primarily sedating, it is accompanied by fast-paced bursts of thought.

LSA contains a large number of psychedelic cognitive effects. The most prominent of these typical effects include:

Visual effects

The visual effects of LSA are mostly present when large doses have been consumed. When compared to LSD and psilocin, the visual effects of LSA are proportionally mild in comparison to the intensity of its accompanying cognitive and physical effects.

Enhancements

Distortions

The visual distortions and alterations are significantly more simplistic than open eye distortions found with other psychedelics. The effects experienced are detailed below:

  • Drifting (melting, breathing, morphing and flowing) - In comparison to other psychedelics, this effect can be described as mild but highly detailed and cartoon-like in appearance. The distortions are fast yet smooth in motion and fleeting in permanence. This is an inconsistently manifested effect with some people never reporting such effects.
  • Colour shifting

Geometry

The visual geometry that is present throughout this trip can be described as more similar in appearance to that of 4-AcO-DMT, ayahuasca and 2C-E than LSD or 2C-B. It can be comprehensively described through its variations as primarily intricate in complexity, abstract in form, organic in appearance, unstructured in organization, dimly lit, multicoloured in scheme, glossy in shading, soft in edges, small in size, slow in speed, smooth in motion, rounded in corners, non-immersive in depth and consistent in intensity. At higher doses, it is significantly more likely to result in states of 8B geometry over 8A geometry.

Hallucinatory states

LSA produces a full range of high level hallucinatory states in a fashion that is very consistent when taken in large doses. The effects of such states include:

  • Transformations - These are extremely common within LSA and partially follow the content of the user's current thought process.
  • Internal hallucinations (autonomous entities; settings, sceneries, and landscapes; alterations in perspective and scenarios and plots) - Unlike LSD, LSA consistently produces moderate to high level hallucinatory states in high doses. This particular effect can be compared to a lucid dream state. The hallucinations are more common within dark environments and can be comprehensively described through their variations as lucid in believability, interactive in style, new experiences in content, controllable and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme. These hallucinations are complemented by a powerful enhancement of one's ability to visualize concepts. This ability eventually becomes so drawn out proportional to dose that it leads to full blown hallucinatory states that are entirely lucid and (for the most part) controllable.

Auditory effects

Natural plant sources

Although the chemical LSA is not legal in some countries, seeds which contain it are found in many gardening stores. The seeds from commercial sources are often coated in some form of pesticide or methylmercury which can result in extreme nausea if ingested. The types of seeds listed below are easily accessible to purchase without pesticide coatings online.

Morning glory seeds

Morning glory seeds

The seeds of many species of morning glory contain lysergamide alkaloids such as the psychedelic known as LSA.[2]

When using morning glory seeds, the dose for oral consumption is generally considered to be:

  • Light: 50 - 100 seeds / 1.5 - 3 g
  • Common: 100 - 250 seeds / 3 - 6 g
  • Strong: 250 - 400 seeds / 6 - 10 g
  • Heavy: 400 + seeds / 10 + g

Hawaiian baby woodrose seeds

Hawaiian baby woodrose seeds

Hawaiian baby woodrose is a perennial climbing vine that is native to the Indian subcontinent and has been introduced to numerous areas worldwide including Hawaii, Africa and the Caribbean. Hawaiian baby woodrose seeds may be consumed for their various lysergamide alkaloids such as LSA.[3]

When using Hawaiian baby woodrose seeds, the dose for oral consumption is generally considered to be:

  • Threshold: 1 - 4 seeds
  • Light: 3 - 6 seeds
  • Common: 5 - 8 seeds
  • Strong: 7 - 12 seeds
  • Heavy: 12 + seeds

Toxicity and harm potential

Main article: Responsible use § Hallucinogens

The toxicity and long-term health effects of recreational LSA use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because LSA is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried LSA suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

LSA is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of LSA are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). LSA presents cross-tolerance with all psychedelics, meaning that after the consumption of LSA all psychedelics will have a reduced effect.

Vasoconstriction

LSA should not be used regularly for long periods of time. When used repeatedly over a short period of time, LSA's vasoconstriction effects build up while the psychoactive effects get weaker. A common sign of vasoconstriction build up can be described as a feeling of painful or uncomfortable legs.[4] This is because not enough blood is getting to the muscles. The upper leg muscles are the largest, most energy consuming muscles in the body and they will feel sore if blood flow to them is lowered even slightly.[5]

If one has taken HBWR seeds, morning glory seeds or pure LSA and is experiencing sore legs then a well needed break is completely necessary. With LSA it can take up to 3 days of abstinence to get back to vasoconstriction baseline.

Legal issues

  • Australia: The consumption, sale and possession of LSA is illegal.
  • The Netherlands: The consumption, sale and possession of LSA is illegal.
  • New Zealand: The consumption, sale and possession of LSA is illegal. The plants and seeds of morning glory species are legal to possess, cultivate, buy and distribute.
  • Sweden: The consumption, sale and possession of LSA is illegal.
  • United Kingdom: LSA is a Class A drug and categorised as a precursor to LSD.
  • United states: As a precursor to LSD, LSA is a DEA Schedule III drug
  • Latvia - LSA itself is illegal. Although it isn't scheduled, it is controlled as an LSD structural analog. However, there is no information about LSA-containing seeds. In Latvia, plants are only illegal if they contain Schedule I controlled substances and LSA is not a Schedule 1 controlled substance.[6]

Preparation methods

Preparation methods for this compound within our tutorial index include:

Experience reports

Anecdotal reports which describe this compound within our experience index include:

Additional experience reports can be found here:

See also

External links

References

  1. ↑ #26. LSD-25 (LA-111, ergine, d-lysergamide) - TIHKAL | http://www.erowid.org/library/books_online/tihkal/tihkal26.shtml
  2. ↑ http://jama.jamanetwork.com/article.aspx?articleid=1165951
  3. ↑ http://www.sciencedirect.com/science/article/pii/S0379073809004745
  4. ↑ http://www.ncbi.nlm.nih.gov/pubmed/11128853
  5. ↑ http://animalsci.highwire.org/content/84/11/3167.short
  6. ↑ Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem | http://likumi.lv/doc.php?id=121086
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