LSA
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LSA
LSA2.png
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Chemical Nomenclature
Common names LSA
Substitutive name d-lysergic acid amide, Ergine, d-lysergamide
Systematic name (8β)-9,10-didehydro-6-methyl-ergoline-8-carboxamide
Routes of Administration


Oral
Dosage
Differs between Morning glory seeds & Hawaiian Baby Woodrose seeds
Duration
Total 5 - 10 hrs
Onset 20mins - 2 hrs
Peak 2 - 7 hrs
Offset 1 - 2 hrs
Afterglow >0 - 3 hrs









LSA (also known as Ergine, d-lysergic acid amide and d-lysergamide) is a naturally occurring hallucinogenic psychedelic alkaloid of the lysergamide family. It is thought to be the active compound within many plants such as Morning Glory seeds, Hawaiian Baby Woodrose seeds and some species of fungi.

LSA was assayed for human activity by Albert Hofmann in self-trials in 1947 (well before it was known to be a natural compound). Intramuscular administration of a 500 microgram dose led to a tired, dreamy state with an inability to maintain clear thoughts. After a short period of sleep, the effects were gone and normal baseline was recovered within five hours.[1]

This suggests that the notion of LSA as the main psychedelic compound within Morning Glory seeds and Hawaiian Baby Woodrose is debatable as these reports suggest that the effects of synthetic LSA are only slightly psychedelic. Therefore it is reasonable to assume that the experience may perhaps instead be triggered by a mixture of various lysergamides within these plant materials instead of one specific compound.

Chemistry

LSA, or lysergic acid amide, is an alkaloid of the lysergamide family. Lysergamides are distinct from both tryptamines and phenethylamines, although the chemical structure is more similar to a tryptamine than a phenethylamine. It lacks the ethyl groups found in LSD, which dramatically decreases its potency.

Pharmacology

Main article: Serotonergic psychedelic

LSA's psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist.

However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely if ever occur all at once but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical effects

The physical effects of LSA can be broken down into several components all of which progressively intensify proportional to dosage. These are described below and generally include:

  • Spontaneous tactile sensations - The "body high" of LSA can be described as a mild yet pleasurable, soft tingling sensation. This is largely noticed in high doses and is accompanied by strong waves of physical euphoria which are usually manifested spontaneously at different unpredictable points throughout the trip but can also maintain a consistent presence. In either case, they steadily rise with the onset and hit their limit once the peak has been reached.
  • Sedation - In terms of its effects on the physical energy levels of the tripper, LSA tends to be sedating, however it can be setting dependent. For example, when taken in settings with large amounts of stimuli or during physically strenuous activities such as walking, running, climbing or dancing it is fully capable of becoming stimulating and energetic. In contrast, however, when taken in calm environments such as darkened rooms with comfortable seating it is consistently relaxing, peaceful and sedating.
  • Vasoconstriction - LSA has strong and pronounced feelings of vasoconstriction throughout the experience of being under its influence. This varies in its intensity between individuals but is often considered as particularly uncomfortable in comparison to other psychedelics.
  • Motor control loss - At high doses this effect becomes far more present than in lower, it can be compared to the loss of motor control experienced with alcohol induced inebriation, and is strengthened by the accompaniment of sensation of increased bodily weight.
  • Increased bodily weight
  • Pupil dilation

Cognitive effects

The cognitive effects of LSA are described by many as extremely relaxing yet lucid and clear headed in its style when compared to other commonly used psychedelics such as LSD or psilocin. Although it is primarily sedating, it is accompanied by fast paced bursts of thought.

LSA contains a large number of psychedelic cognitive effects. The most prominent of these typical effects include:

Visual effects

The visual effects of LSA are mostly present when large doses have been consumed and proportionally mild in comparison to the intensity of its accompanying cognitive and physical effects when compared to substances such as LSD and psilocin.

Enhancements

LSA presents a full and complete array of potential visual enhancements which generally includes:

Distortions

As for visual distortions and alterations, these are significantly more simplistic from that of open eye distortions found with other psychedelics. Effects experienced are detailed below:

  • Drifting (melting, breathing, morphing and flowing) - In comparison to other psychedelics, this effect can be described as mild but highly detailed yet cartoon-like in appearance. The distortions are fast yet smooth in motion and fleeting in their permanence. This is an inconsistently manifested effect with some never reporting such effects.
  • Colour shifting

Geometry

The visual geometry that is present throughout this trip can be described as more similar in appearance to that of 4-AcO-DMT, Ayahuasca and 2C-E than LSD or 2C-B. It can be comprehensively described through its variations as primarily intricate in complexity, abstract in form, organic in appearance, unstructured in organization, dimly lit, multicoloured in scheme, glossy in shading, soft in edges, small in size, slow in speed, smooth in motion, rounded in corners, non-immersive in depth and consistent in intensity. At higher dosages it is significantly more likely to result in states of 8B Geometry over 8A Geometry.

Hallucinatory states

LSA produces a full range of high level hallucinatory states in a fashion that is very consistent when taken in large doses. The effects of such states include:

  • Transformations - These are extremely common within LSA and partially follow the content of the user's current thought process.
  • Internal hallucinations (Autonomous entities, Settings, sceneries, and landscapes, Alterations in perspective and Scenarios and plots) - Unlike LSD, LSA consistently produces moderate to high level hallucinatory states in high doses. This particular effect can be compared to a lucid dream state. They are more common within dark environments and can be comprehensively described through their variations as lucid in believability, interactive in style, new experiences in content, controllable and almost exclusively religious, spiritual, mystical or transcendental in their overall theme. These hallucinations are complemented by a powerful enhancement of one's ability to visualize concepts. This ability eventually becomes so drawn out proportional to dosage that it leads to full blown hallucinatory states that are entirely lucid and for the most part controllable.

Auditory effects

The auditory effects of LSA are common in their occurrence and exhibit a full range of effects which commonly includes:

Natural plant sources

Although the chemical LSA is not legal in some countries, seeds which contain it are found in many gardening stores; however, the seeds from commercial sources are often coated in some form of pesticide or methylmercury which can result in extreme nausea if ingested. The types of seeds listed below are freely available to purchase without pesticide coatings online.

Morning Glory seeds

Morning Glory seeds.

The seeds of many species of Morning Glory contain lysergamide alkaloids such as the psychedelic known as LSA.[2]

When using Morning Glory seeds, the dosage for oral consumption is generally considered to be:

  • Light : 50 - 100 seeds / 1.5 - 3 g
  • Common : 100 - 250 seeds / 3 - 6 g
  • Strong : 250 - 400 seeds / 6 - 10 g
  • Heavy : 400 + seeds / 10 + g

Hawaiian Baby Woodrose seeds

Hawaiian Baby Woodrose seeds.

Hawaiian Baby Woodrose is a perennial climbing vine that is native to the Indian subcontinent and has been introduced to numerous areas worldwide including Hawaii, Africa and the Caribbean. Hawaiian Baby Woodrose seeds may be consumed for their various lysergamide alkaloids, such as LSA.[3]

When using Hawaiian Baby Woodrose seeds the dosage for oral consumption is generally considered to be:

  • Threshold : 1 - 4 seeds
  • Light : 3 - 6 seeds
  • Common : 5 - 8 seeds
  • Strong : 7 - 12 seeds
  • Heavy : 12 + seeds

Preparation recipes

Toxicity and harm potential

Vasoconstriction

LSA should not be used regularly for long periods of time. When used repeatedly over a short period of time LSA's vasoconstriction effects build up while the psychoactive effects get weaker. A common sign of vasoconstriction build up can be described as feeling of painful or uncomfortable legs.[4] This is because not enough blood is getting to the muscles. The upper leg muscles are the largest, most energy consuming muscles in the body and they will feel sore if blood flow to them is lowered even slightly. [5]

If one has taken HBWR seeds, Morning Glory seeds or pure LSA and is experiencing sore legs a well needed break is completely necessary. With LSA it can take up to 3 days of abstinence to get back to vasoconstriction baseline.

Lethal dosage

The LD50 of LSA for human beings has never been reached in any setting, but is thought to be incredibly high, similar to LSD. There are not any known deaths associated directly with pharmacological causes of LSA, but rather due to self-harm, impaired judgement, and drug interactions.

Tolerance and addiction potential

LSA is non-habit forming and the desire to use it can actually decrease with use. It is most often self-regulating.

An almost immediate tolerance is built to LSA after ingestion, preventing one from experiencing its full effects more often than every 4-7 days unless they increase their dose significantly.

Legal issues

  • Australia: The consumption, sale and possession of LSA is illegal.
  • The Netherlands: The consumption, sale and possession of LSA is illegal.
  • New Zealand: The consumption, sale and possession of LSA is illegal. The plants and seeds of Morning Glory species are legal to possess, cultivate, buy, and distribute.
  • Sweden: The consumption, sale and possession of LSA is illegal.
  • United Kingdom: LSA is a Class A drug, categorised as a precursor to LSD.
  • United states: As a precursor to LSD, LSA is a DEA schedule III drug

Experience reports

Anecdotal reports which describe this compound within our experience index include:

See also

References

  1. ↑ #26. LSD-25 (LA-111, ergine, d-lysergamide) - TIHKAL | http://www.erowid.org/library/books_online/tihkal/tihkal26.shtml
  2. ↑ http://jama.jamanetwork.com/article.aspx?articleid=1165951
  3. ↑ http://www.sciencedirect.com/science/article/pii/S0379073809004745
  4. ↑ http://www.ncbi.nlm.nih.gov/pubmed/11128853
  5. ↑ http://animalsci.highwire.org/content/84/11/3167.short
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