25D-NBOMe

Many drugs in the NBOMe series have been fatal at heavy doses.

It is strongly discouraged to take large amounts of this substance or to insufflate (snort) it. Please see this section for more details.

25D-NBOMe
The skeletal formula of 25D-NBOMe
Chemical Nomenclature
Common names	25D-NBOMe
Substitutive name	2,5-dimethoxy-4-methyl
Systematic name	1-2-(2,5-dimethoxy-4-methylphenyl)-N-(2-methoxybenzyl)ethanamine
Class Membership
Psychoactive class	Psychedelic
Chemical class	Phenethylamine
Routes of Administration
Sublingual Dosage WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation. This dosage and duration information has been sourced from TripSit Threshold 300 µg Light 300 - 800 µg Common 800 - 1200 µg Strong 1200+ µg Heavy The NBOMe series can be fatal at heavy doses. Duration Total 4 - 6 hours Onset 20 - 40 minutes Peak 1 - 2 hours Offset 1 - 2 hours After effects > 6 hours Insufflated Dosage WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy. Heavy The NBOMe series can be fatal when insufflated. It is strongly discouraged. Duration

Summary sheet: 25D-NBOMe

25D-NBOMe (2C-D-NBOMe) is a derivative of the substituted phenethylamine psychedelic 2C-D discovered in 2004 by Ralf Heim at the Free University of Berlin, and subsequently investigated by a team at Purdue University led by David Nichols. This chemical had no history of human use prior to being sold online as a designer drug in 2010.

Chemistry

25D-NBOMe, or 2C-D-NBOMe, is a serotonergic N-benzyl derivative of the substituted phenethylamine psychedelic known as 2C-D. 25D-NBOMe is a substituted phenethylamine with methoxy groups CH3-O- attached to carbons R₂ and R₅ as well as a methyl group attached to carbon R₄. It differs from 2C-D structurally through a substitution on the amine (NH2) with a 2-methoxybenzyl (BOMe) group as shown in the image to the right. 25D-NBOMe shares this 2-methoxybenzyl substitution with other chemicals of the NBOMe family. This NBOMe addition contains a methoxy ether CH3-O-R bound to a benzene ring at R₂.

Pharmacology

25D-NBOMe has efficacy at the 5-HT_2A receptor where it acts as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive. The addition of the NBOMe group to the structure results in a sixteen fold increase in potency when compared to 2C-D, allowing even the most extreme of doses to fit in liquid form onto tabs and blotter paper, which people often mistake for LSD.

Subjective effects

The effects listed below are based upon the subjective effect index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical effects

The physical effects of 25D-NBOMe can be broken down into several components which progressively intensify proportional to dosage. These are described below and generally include:

• Sedation - In terms of its effects on the subject's physical energy levels, 25D-NBOMe is considered to be sedating. The sedation can be considered slightly less intense than other psychedelics such as psilocin and 4-AcO-DMT.
• Sublingual numbing - Assuming the substance has been taken sublingually, the very first physical effect which a person will notice immediately after sublingual absorption is a strong, unpleasant, metallic chemical taste. This is accompanied by a very obvious feeling of general numbness of the tongue and mouth which can stay for up to an hour after the blotter paper has been consumed. This is the key difference when it comes to determining whether your blotter paper contains LSD or one of the NBOMe series.
• Perception of increased weight
• Tactile hallucinations
• Nausea - As the tripper begins to come up, nausea is not uncommon and can sometimes result in initial vomiting. It passes once this has happened or the trip begins to fully set in. In comparison to other psychedelics such as psilocin, LSD, 2C-E and 2C-I, this could actually be very considered very mild in its intensity.
• Vasoconstriction
• Increased heart rate
• Pupil dilation
• Wakefulness

Cognitive effects

The cognitive effects of 25D-NBOMe are remarkably light and underwhelming in comparison to more traditional psychedelics. It is not uncommon for people to report feeling that their thought stream has maintained general normality in its specific style throughout moderate to high doses. At heavy doses, however, mild cognitive alterations become present; this dose seems to be lower in proportion to physical effects when compared to 25I-NBOMe.

The most prominent of these cognitive effects generally include:

• Analysis enhancement
• Thought deceleration
• Time distortion
• Novelty enhancement
• Conceptual thinking
• Emotion enhancement
• Personal bias suppression
• Memory suppression
• Ego death

Visual effects

Enhancements

25D-NBOMe presents a mild array of possible visual enhancements which generally includes:

• Visual acuity enhancement
• Colour enhancement
• Pattern recognition enhancement

Distortions

The visual distortions and alterations which are experienced are detailed below:

• Drifting (melting, flowing, breathing and morphing) - In comparison to other psychedelics, this effect can be described as bland, slow and smooth in motion, inconsistent in appearance and unrealistic/cartoon-like in style.
• Tracers
• After images
• Symmetrical texture repetition
• Colour shifting
• Diffraction

Geometry

The visual geometry that is present throughout this trip is often described as very similar in appearance to that of DOM. It can be comprehensively described as smooth and organic in style, simple in complexity, fine and zoomed out in detail, slow and fluid in motion, structured in shape, colourful in scheme, bright in colour, and rounded across its corners.

In terms of its behaviour, 25D-NBOMe’s geometry leads onto level 8A visual geometry with level 8B remaining so far unconfirmed within this substance. It also seems to consistently build up in visual intensity when the tripper stares at a central point. This eventually envelopes the visual field and creates the sensation that the tripper has broken through into a continuously shifting geometric landscape or structure with a vast sense of physical size attributed to it.

Hallucinatory states

25D-NBOMe is capable of producing a full range of hallucinatory states within the level 1 - 3 range extremely consistently within doses higher than of 2mg. These effects include:

• Transformations
• Internal hallucinations - (settings, sceneries, and landscapes; alterations in perspective and scenarios and plots)
• External hallucinations - (autonomous entities; settings, sceneries, and landscapes; alterations in perspective and scenarios and plots)

Toxicity and harm potential

Main articles: Research chemicals § Toxicity and harm potential & Responsible use § Hallucinogens

25D-NBOMe is a very new substance, and very little is known about its pharmacological risks or its interaction with other substances. The LD50 has not yet been determined. Due to 25D-NBOMe's extreme potency, it should not be insufflated (snorted) as this method of administration appears to have led to several deaths from other NBOMe compounds in the past year.

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

In terms of its addictive potential, 25D-NBOMe has not been studied formally but many users experience a self-regulating quality. Also, due to its immediate tolerance build up, which lasts up to 2 - 3 weeks after the experience, it is difficult to use this substance compulsively.

Legal issues

• Sweden: 25D-NBOMe is classed as Schedule I
• U.K.: On the 10th of June 2014, all NBOMes became Class A drugs which means that they’re illegal to have, give away or sell. Possession could get one up to seven years in jail and/or an unlimited fine. Supplying someone else could result in a heavy jail time sentence between a minimum of eight years and a life sentence and/or an unlimited fine.
• Latvia: 25D-NBOMe is a Schedule I controlled substance.

See also

• Responsible use
• 25x-NBOMe
• 25I-NBOMe
• 25B-NBOMe
• Psychedelics
• Phenethylamines