25C-NBOMe

25C-NBOMe can be fatal at heavy doses (as low as 4mg).

It is strongly discouraged to take large amounts of this substance or to insufflate (snort) it. Please see this section for more details.

25C-NBOMe
The skeletal formula of 25C-NBOMe
Chemical Nomenclature
Common names	25C-NBOMe
Substitutive name	NBOMe-2C-C, 2C-C-NBOMe
Systematic name	2-(4-chloro-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine
Class Membership
Psychoactive class	Psychedelic
Chemical class	Phenethylamine
Routes of Administration
Sublingual Dosage WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation. This dosage and duration information has been sourced from TripSit Threshold 50 - 100 µg Light 150 - 300 µg Common 300 - 700 µg Strong 700 - 1000 µg Heavy 25C-NBOMe can be fatal at heavy doses. Duration Total 8 - 10 hours Onset 0 - 15 minutes Come up 30 - 90 minutes Peak 4 - 6 hours Offset 1 - 4 hours

Blotter paper containing 25C-NBOMe

Summary sheet: 25C-NBOMe

25C-NBOMe (2C-C-NBOMe) is a derivative of the substituted phenethylamine psychedelic 2C-C, discovered in 2003 by Ralf Heim at the Free University of Berlin, and subsequently investigated by a team at Purdue University led by David Nichols. It has been studied in its 11C radiolabelled form as a potential ligand for mapping the distribution of 5-HT2A receptors in the brain, using positron emission tomography (PET).

It is worth noting that compounds of the NBOMe class are not orally active and should therefore be taken sublingually by simply placing the substance into one's mouth and allowing it to slowly absorb over a period of 30 minutes.

This chemical had no history of human use prior to being sold online as a designer drug in 2010.

Chemistry

A comparison of 25C-NBOMe and 2C-C.

25C-NBOMe or 2C-C-NBOMe is a serotonergic N-benzyl derivative of the substituted phenethylamine psychedelic known as 2C-C. 25C-NBOMe is a substituted phenethylamine with methoxy groups CH3-O- attached to carbons R₂ and R₅ as well as a chlorine attached to carbon R₄. It differs from 2C-C structurally through a substitution on the amine (NH2) with a 2-methoxybenzyl (BOMe) group as shown in the image to the right. 25C-NBOMe shares this 2-methoxybenzyl substitution with other chemicals of the NBOMe family. This NBOMe addition contains a methoxy ether CH3-O-R bound to a benzene ring at R₂.

Pharmacology

Main article: Serotonergic psychedelic

25C-NBOMe has efficacy at the 5-HT_2A receptor where it acts as a potent partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

In comparison to 2C-C, the addition of an NBOMe group to the structure results in a sixteen fold increase in potency, allowing even the most extreme of dosages to fit in liquid form onto tabs and blotter paper, which people often mistake for LSD. In comparison to LSD however it is only a third of the potency.

Subjective effects

The effects listed below are based upon the subjective effect index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical effects

• Stimulation and Sedation - In terms of its effects on the subject's physical energy levels, 25C-NBOMe is considered to be energetic and well as sedating, leaving the subject in a state of equilibrium between being stationary and moving. The physical stimulation manifested by this substance can be described as similar to 2C-B , and is commonly experienced as simultaneously easygoing and physically difficult, sometimes presenting overstimulation which results in bodily shakes and teeth grinding. The levels of stimulation can be considered less intense than 25I-NBOMe and the sedation can be considered slightly less intense than other psychedelics such as Psilocin and 2C-C.
• Sublingual numbing - Assuming the substance has been taken sublingually, the very first physical effect which a person will notice immediately after sublingual absorption is a strong, unpleasant metallic chemical taste. This is accompanied by a very obvious feeling of general numbness of the tongue and mouth which can stay for up to an hour after the blotter paper has been consumed. This is the key difference when it comes to determining whether your blotter paper contains LSD or one of the NBOMe series.
• Temperature regulation suppression
• Spontaneous tactile sensations - The "body high" itself can be described as a generally mild, all-encompassing, soft but euphoric tingling sensation. This tingling sensation is also accompanied by spontaneous rushes of euphoria that become longer and more drawn out proportional to the dosage consumed.
• Perception of decreased weight - In terms of the body’s perceived weight, this substance consistently leaves people feeling extremely light, often to the point of total weightlessness.
• Tactile hallucinations
• Changes in gravity - Compared to classic tryptamines, this effect is considerably less intense than what is commonly experienced with DMT and Psilocin.
• Nausea - As the tripper begins to come up, nausea is not uncommon and can sometimes result in initial vomiting, but passes once this has either happened or the trip begins to fully set in. In comparison to other psychedelics such as psilocin, LSD, 2C-E and 2C-I, this could actually be very considered very mild in its intensity.
• Vasoconstriction
• Increased heart rate
• Pupil dilation
• Wakefulness
• Increased blood pressure

Cognitive effects

The cognitive effects of 25C-NBOMe are described by many as remarkably light and underwhelming in comparison to more traditional psychedelics. It is not uncommon for people to report feeling that their thought stream has maintained general normality in its specific style throughout low to moderate dosages. At high dosages, however, mild to overwhelming cognitive alterations become present; this dosage seems to be lower in proportion to physical effects when compared to 25I-NBOMe.

The most prominent of these cognitive effects generally include:

• Analysis enhancement - This component is consistently manifested only in the context of a non-social setting in which the user is alone and is introspection dominant.
• Empathy, love and sociability enhancement - The entactogenic effects range from mild to powerful, but are inconsistently manifested. Entactogenic effects for people who try this substance usually become prominent in the presence of others. These feelings of increased sociability, love and empathy do not seem to be quite as strong or profound as those found within other entactogens (such as MDMA, 2C-B and AMT)
• Thought acceleration
• Analysis enhancement
• Time distortion
• Immersion enhancement
• Increased music appreciation
• Novelty enhancement
• Conceptual thinking
• Thought connectivity
• Emotion enhancement
• Personal bias suppression
• Memory suppression
• Ego death
• Increased libido

Visual effects

Enhancements

• Visual acuity enhancement
• Colour enhancement
• Pattern recognition enhancement

Distortions

• Drifting (melting, flowing, breathing and morphing) - In comparison to other psychedelics this effect can be described as highly detailed, slow and smooth in motion, static in appearance and unrealistic/cartoon-like in style.
• Tracers
• After images
• Symmetrical texture repetition
• Colour shifting
• Scenery slicing
• Transformations
• Environmental cubism
• Diffraction
• Recursion

Geometry

The visual geometry that is present throughout this trip is often described as very similar in appearance to that of LSD. They can be comprehensively described as algorithmic in geometric style, intricate in complexity, fine and zoomed out in detail, fast and smooth in motion, structured in shape, colourful in scheme, glossy in colour, sharp around the edges and mostly rounded across their corners. In comparison to other more commonly used psychedelics, they can be described as significantly more intricate than the visual geometry found within 2C-I and most of the 2C-x family in general as well as completely on par with LSD, Psilocin and DMT at appropriately high dosages, which seem lower in proportion to the accompanying physical effects when compared to that of 25I-NBOMe.

In terms of their behaviour, 25C-NBOMe’s geometry leads onto Level 8A visual geometry with Level 8B remaining so far unconfirmed within this substance. They also seem to consistently build up in visual intensity when the tripper stares at a central point. This eventually envelopes the visual field and creates the sensation that the tripper has broken through into a continuously shifting geometric landscape or structure with a vast sense of immersive physical size attributed to it.

Hallucinatory states

25C-NBOMe is capable of producing a full range of hallucinatory states within the level 1 - 3 range extremely consistently. However, level 4 - 5 hallucinatory breakthroughs are reported but very uncommon and inconsistent in comparison to other more commonly used psychedelics such as psilocin, 2C-E and DMT. This can be considered as on par with and identical in behaviour to that of LSD and 25I-NBOMe.

These effects include:

• Transformations
• Internal hallucinations - (autonomous entities; settings, sceneries, and landscapes; alterations in perspective and scenarios and plots) These are more common within dark environments and can be described as internal in their manifestation, lucid in believability, interactive in style and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.
• External hallucinations - (autonomous entities; settings, sceneries, and landscapes; alterations in perspective and scenarios and plots). These are often manifesting as rapidly moving, interactive solid and typically asymmetrical matter or physical beings reflecting imagined concepts. They are more common in bright environments and can be described as external in their manifestation, equally lucid and delirious in believability, interactive in style, autonomous in interaction, and almost exclusively alien, mystical, or a transcendental nature in their overall theme.

Auditory effects

• Enhancements
• Distortions
• Hallucinations

Toxicity and harm potential

Main articles: Research chemicals § Toxicity and harm potential & Responsible use § Hallucinogens

25C-NBOMe is a relatively new substance, and little is known about its pharmacological risks or its interaction with other substances. The LD50 has not yet been determined although it can be fatal at heavy dosages. 25C-NBOMe overdoses have also been linked to multi-organ failure.

It is advised that due to 25C-NBOMe's extreme potency it should not be insufflated (snorted) as this method of administration has been attributed to several fatal overdoses due to improper dosing.

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

25C-NBOMe is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of 25C-NBOMe are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 25C-NBOMe presents cross-tolerance with all psychedelics, meaning that after the consumption of 25C-NBOMe all psychedelics will have a reduced effect.

Legal issues

• Sweden: 25C-NBOMe is classed as Schedule I.
• UK: On 10 June 2014, all NBOMe's became Class A drugs which means that they’re illegal to have, give away or sell. Possession could get one up to seven years in jail and/or an unlimited fine. Supplying someone else, could result in a heavy jail time sentence, between a minimum of eight years and a life sentence and/or an unlimited fine.
• Israel - The NBOMe series of psychoactives became controlled in Israel in May, 2013.
• New Zealand - 25C-NBOMe was sold as a designer drug in New Zealand in early 2012, but was withdrawn from sale after a statement by Associate Health Minister Peter Dunne that 25C-NBOMe would be considered to be substantially similar in chemical structure to the illegal hallucinogen DOB, and was therefore a Class C controlled drug analogue.
• Russia - Russia became the first country to regulate the NBOME class. The entire NBOMe series of psychoactives became controlled in the Russian Federation starting October, 2011.
• United States - Several NBOMe series compounds will be temporarily scheduled in the United States for 2 years with the possibility of an additional year. The temporary scheduling applies to 25C-NBOMe, 25B-NBOMe, and 25I-NBOMe.
• China - As of October 2015 25C-NBOMe is a controlled substance in China.
• Latvia: 25C-NBOMe is a Schedule I controlled substance.

Experience reports

Anecdotal reports which describe this compound within our experience index include:

• Experience:2mg 25C-NBOMe - Experimental trip to test personal limits of NBOMes

Additional experience reports can be found here:

• Erowid Experience Vaults: 25C-NBOMe

See also

• Responsible use
• 25x-NBOMe
• 25I-NBOMe
• 25B-NBOMe
• Psychedelics
• Phenethylamines

External links

• 25C-NBOMe (Wikipedia)
• 25C-NBOMe (Erowid)
• 25C-NBOMe (Disregard Everything I Say)
• 25C-NBOMe (TripSit)
• 25C-NBOMe experiences (Erowid)