DOB

DOB
The skeletal formula of DOB.
Chemical Nomenclature
Common names	DOB
Substitutive name	Brolamfetamine, Bromo-DMA, 4-Bromo-2,5-dimethoxy-amphetamine
Systematic name	1-(4-Bromo-2,5-dimethoxyphenyl)-2-aminopropane
Class Membership
Psychoactive class	Psychedelic
Chemical class	Phenethylamine
Routes of Administration
Oral Dosage WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy. Threshold 0.2 mg Light 0.2 - 0.75 mg Common 0.75 - 1.75 mg Strong 1.75 - 2.5 mg Heavy 2.5 - 3.5 mg + Duration Total 7 - 17 hours Onset 30 - 90 minutes Peak 3 - 8 hours Offset 3 - 8 hours After effects 4 - 8 hours

Summary sheet: DOB

Dimethoxybromoamphetamine, also known as DOB, Brolamfetamine and Bromo-DMA, is a psychedelic drug of the substituted phenethylamine and amphetamine chemical classes.

This substance has no history of human usage prior to the 1991 publication of its synthesis and pharmacology in PiHKAL (Phenethylamines i Have Known And Loved) by Alexander Shulgin. In modern times, it is used as a recreational drug and an entheogen, rarely sold on the streets and almost exclusively obtained as a grey area research chemical through the use of online vendors.

Chemistry

DOB or 4-Bromo-2,5-dimethoxy-amphetamine is a molecule of the amphetamine class. Amphetamines are substituted phenethylamines containing a phenyl ring bound to an amino (NH₂) group through an ethyl chain and a methyl group bound to the alpha carbon R_α. DOB contains methoxy functional groups CH₃O- attached to carbons R₂ and R₅ as well as a bromine attached to carbon R₄ of the phenyl ring. DOB is the amphetamine analogue of the phenethylamine 2C-B.

Pharmacology

Main article: Serotonergic psychedelic

DOB's psychedelic effects are believed to come from its efficacy at the 5-HT_2A receptor as a partial agonist. Due to its selectivity, DOB is often used in scientific research when studying the 5-HT2 receptor subfamily. It has been suggested that DOB is a prodrug metabolized in the lungs.

However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely if ever occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical effects

• Spontaneous tactile sensations - The "body high" of DOB is manifested as somewhat intense in comparison to most classical psychedelics such as LSD. The sensation itself can be described as a constantly present yet somewhat mild energetic pins and needles sensation that encompasses a person’s entire body. It is usually static in its position and felt over every square inch of the skin as if it was coming from behind the user's body. Occasionally, however, it manifests itself in the form of a continuously shifting tingling sensation that travels up and down the body in spontaneous waves.
• Stimulation - In terms of its effects on the physical energy levels of the tripper, DOB is usually considered to be extremely stimulating at levels which do not become overwhelming and are encouraged instead of forced. This results in a shakiness and unsteadiness of the hands at high dosages, but encourages the person to move around, run, dance, climb and generally engage in physical activities. The level of stimulation varies between users with some people reporting it to be somewhat similar to amphetamine in its intensity and others reporting that it is extremely subtle even at higher dosages. In comparison, other more commonly used psychedelics such as psilocin are generally sedating and relaxed.
• Tactile enhancement - Feelings of enhanced tactile sensation are consistently present at moderate levels throughout most DOB trips.
• Nausea - Mild to extreme nausea is reported when consumed in moderate to high dosages and either passes once the person has vomited or gradually fades by itself as the peak sets in.
• Vasoconstriction - This effect is usually only present at higher dosages but can be particularly uncomfortable.
• Increased heart rate
• Pupil dilation
• Increased blood pressure

Cognitive effects

The head space of DOB is described by many as one of mental stimulation and a powerful enhancement of a person's current mental state. Many users report that it may not be as deep as other traditional psychedelics such as LSD or psilocin and that it is comparatively empty in terms of its insightfulness.

The total sum of these cognitive components regardless of the setting generally includes:

• Empathy, love and sociability enhancement - This component is inconsistently manifested only in the context of social settings in which one is within the company of others. These feelings of sociability, love and empathy are much weaker and less sharp than those found on substances such as MDMA and 2C-B, but still prove strong enough to provide therapeutic effects.
• Analysis enhancement
• Thought acceleration
• Time distortion
• Novelty enhancement
• Conceptual thinking
• Immersion enhancement
• Emotion enhancement
• Memory suppression
• Ego death
• Wakefulness

Visual effects

Enhancements

• Visual acuity enhancement
• Colour enhancement
• Pattern recognition enhancement

Distortions

• Drifting (melting, flowing, breathing and morphing) - In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion, static in appearance and unrealistic/cartoon-like in style.
• Tracers
• After images
• Symmetrical texture repetition
• Colour shifting
• Scenery slicing

Geometry

The visual geometry that is present throughout this trip can be described as more similar in appearance to that of LSD, 25I-NBOMe or 2C-B than that of ayahuasca, psilocin or 2C-E. It can be comprehensively described through its variations as intricate in complexity, algorithmic in form, synthetic in feel, brightly lit, multicoloured in scheme, glossy in shading, sharp in edges, large in size, fast in speed, smooth in motion, equally rounded and angular in its corners, non-immersive in depth and consistent in intensity. Higher dosages are significantly more likely to result in states of Level 8A visual geometry over Level 8B.

Hallucinatory states

DOB is capable of producing a full range of low and high level hallucinatory states in a fashion that is significantly less consistent and reproducible than that of many other commonly used psychedelics. These effects include:

• Transformations
• External hallucinations
• Internal hallucinations (autonomous entities; settings, sceneries, and landscapes; alterations in perspective and scenarios and plots) - Although DOB is technically capable of producing hallucinatory states in a fashion that is on par with psilocin or DMT in its vividness and intensity, in comparison, these effects are extremely rare and inconsistent. Whilst traditional psychedelics such as LSA, ayahuasca and mescaline will induce internal hallucinations near consistently at level 5 geometry and above, DOB will for most simply go straight into Level 8A geometry. This lack of consistently induced hallucinatory breakthroughs means that for most, DOB is simply not as deep of an experience as certain other psychedelics.

Auditory effects

• Enhancements
• Distortions
• Hallucinations

Toxicity and harm potential

Main articles: Research chemicals § Toxicity and harm potential & Responsible use § Hallucinogens

The toxicity and long-term health effects of recreational DOB use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because DOB is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried DOB suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

DOB is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of DOB are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). DOB presents cross-tolerance with all psychedelics, meaning that after the consumption of DOB all psychedelics will have a reduced effect.

Legal issues

• International: DOB is a Schedule I drug under the Convention on Psychotropic Substances.
• Australia: DOB is listed as Schedule II.
• Canada: It is listed as a Schedule 1 as it is an analogue of amphetamine.
• New Zealand: DOB is Schedule I (Class A) in New Zealand. DOB would also qualify as an analogue under New Zealand's catch-all analogues section in Schedule 3 / Class C of their drug laws which would make 2C-I, 2C-E, DOI, DOB, ephedrine, and pseudoephedrine Schedule 3 compounds in the country.
• Poland: DOB is controlled in Poland.
• U.K.: DOB is Schedule I/Class A in the U.K., making it illegal to sell, buy, or possess without a license.
• U.S.: DOB is Schedule I in the U.S., making it illegal to sell, buy, gift, produce or possess without a DEA license.
• Latvia: DOB is a Schedule I controlled substance.

Experience reports

Anecdotal reports which describe this compound within our experience index include:

• Experience:My DOB Nightmare

Additional experience reports can be found here:

• Erowid Experience Vaults: DOB

See also

• Responsible use
• DOx
• DOC
• DOM
• 2C-B

External links

• DOB (Wikipedia)
• DOB (Erowid)
• DOB experiences (Erowid)
• DOB (TripSit)
• DOB (Bluelight)